Award Data

Dopamine receptors are a family of G protein-coupled receptors (GPCRs), and can be further divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subfamilies. In this proposal, we focus on D1 receptor, which is widely expressed in brain at high levels. Modulation of D1 activity is implicated in the treatment of many psychiatric and neurological disorders, such as schizophrenia, attention def ...

PROJECT SUMMARY GoDx, Inc. has been developing a prototype multiplexed paper strip device for the detection of the DNA and RNA of gastrointestinal pathogens at the point-of-need in andlt; 30 minutes with funding from the NCATS SBIR parent grant TR 001912. We have used the same platform technology we are developing in the parent grant to develop a rapid (andlt;30 minute), low-cost and instrument-fr ...

The SBIR Phase II proposal outlines the approach of Night Crew Labs (NCL) in designing, and developing, and testing a system prototype to perform Global Navigation Satellite System radio occultations (GNSS-ROs) from a high-altitude balloon platform. NCL will continue building from the positive results achieved in Phase I that successfully demonstrated the feasibility of performing balloon-borne GN ...

Phase-1 demonstrated the powerful and unusual remote sensing opportunities available by adding acoustic signal detection to pop-up satellite tags (PSAT). The time and location of spawning define the starting point in the life history of fish. Yet this event, which is of critical importance to fishery researchers and managers seeking to gain an understanding of distinct reproductive populations and ...

Subsurface mooring beacons are used to provide notifications and assist in locating moored assets that have surfaced and are free drifting. Their nominal design is driven by the requirements for offshore use where they need to survive extreme depths and remote deployment, most often using satellite constellations for communication and geo-location. Existing beacons serve their purpose well, but th ...

The presence of fog reduces visibility, contributing to unsafe conditions for many maritime tasks. The current system uses active backscatter and has high power requirements, high maintenance and replacement costs. Areté Associates’ innovative FogViewer system comprises a passive multi-spectral, multi-polarization sensor suite that leverages available degrees of freedom to best characterize the ...

The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

Advances in materials and automation are rapidly reshaping the American manufacturing economy, and must be embraced to sustain a strong manufacturing sector in the United States. Additive manufacturing is possibly the fastest growing example of this trend, growing at an astonishing compound annual growth rate of 25.7%. The plastic materials market for additive manufacturing, valued at $700M in 202 ...

Polyfluoroalkyl substances (PFAS) are used in food packaging, as coatings for cloth (e.g. Scotchgard), firefighting foams, electronics, and industrial and automotive components. Being perfluorinated species, they are engineered to breakdown slowly (half-life >92 years in water), and thus persist for very long times. Their high water-solubility makes them especially dangerous, and much like perchlo ...

To reach the end user, oil and gas production at the wellhead must be transmitted through the country and distributed to a wide range of customers. This logisticalsystem requires natural gas gathering lines, processing facilities,product storage tanks and Jots of other equipment. What results is air pollution caused by industry losses during these operations and the use of continuous or intermitte ...