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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Bottom Feeder- A Highly Maneuverable Autonomous Underwater Vehicle

    SBC: Tridentis Advanced Marine Vehicles LLC            Topic: 822

    The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

    SBIR Phase II 2019 Department of CommerceNational Oceanic and Atmospheric Administration
  2. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

    SBC: Brain Electrophysiology Laboratory Company, LLC            Topic: 101

    This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Whole-organ bioreactor with integrated nondestructive 3D molecular imaging

    SBC: Sonovol, Inc.            Topic: NHLBI

    Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies

    SBC: IsoPlexis            Topic: NCI

    While CAR T therapies have advanced in the clinicthere are still two specific issues using these breakthrough therapies for blood cancersDurable responses in patients are only atand Cytokine Release Syndrome occurs inof treated patientsThese limitationsfor a drug that costs as much as $may cost an additional $for treating adverse events leading to caution for many clinical centers to administer th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a New Carbohydrate-based Anticoagulant Drug

    SBC: Glycan Therapeutics LLC            Topic: NHLBI

    Low molecular weight heparinsLMWHsare partially depolymerized natural products of heparinwhich are isolated from porcine intestineA worldwide distribution of contaminated heparin inwas associated withdeaths in the USThis crisis revealed the vulnerability of the LMWH supply chainLMWHs are complex mixtureshaving average molecular masses ofDaltonscorresponding tosaccharide unitsThe efficient preparat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Low cost retinal optical coherence tomography for point of care use

    SBC: Lumedica, Inc            Topic: NEI

    The objective of this research is to create a clinical prototype of a new optical coherence tomographyOCTsystem suitable for diagnostic retinal imaging at the point of careThe target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systemsBy breaking the $system barrier we will provide an in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions

    SBC: Baebies, Inc.            Topic: NICHD

    An estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Culturally Responsive Stress Reduction: A Mobile Mindfulness Application toSupport Health Promotion for African Americans

    SBC: IRIS MEDIA INC            Topic: 102

    ABSTRACTThe proposed interventionCulturally Responsible Stress ReductionA Mobile Mindfulness Application to Support Health Promotion for African AmericansCRSRis designed to encourage the use of mindfulness to mitigate the disproportionate amount of stress related health disparities facing African AmericansCurrent mindfulness approaches have been unsuccessful in engaging this populationThis proposa ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. System for faster microarray assays and end-to-end workflow automation

    SBC: Redbud Labs, Inc.            Topic: 400

    ABSTRACTMicroarrays are an important research toolgenomics and proteomicsand clinical toolbiomarker discovery and diagnosisCurrent microarray processing methods are limited by slow assay kineticsare not amenable to automationand require high volume of expensive reagents buffersMiniaturization of these technologies has been explored to improve throughputThe demand for microarrays continues to grow ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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