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Award Data
The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.
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Bottom Feeder- A Highly Maneuverable Autonomous Underwater Vehicle
SBC: Tridentis Advanced Marine Vehicles LLC Topic: 822The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...
SBIR Phase II 2019 Department of CommerceNational Oceanic and Atmospheric Administration -
Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections
SBC: Zymeron Corporation Topic: NIAIDCytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
TOPIC 356: FLUOROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION
SBC: Lucerna Inc. Topic: NCICircular RNAscircRNAsare a novel class of modified RNAs that are an abundant component of the epitranscriptomePutative functions of circRNAsinclude miRNA sequestrationRNA binding protein scaffoldingmRNA trappingand protein translation regulationDeregulation in one or more of these roles has been linked to several types of cancerOne well studied circRNAciRSis believed to act as a miRNAsponge and in ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation
SBC: Brain Electrophysiology Laboratory Company, LLC Topic: 101This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Whole-organ bioreactor with integrated nondestructive 3D molecular imaging
SBC: Sonovol, Inc. Topic: NHLBIAbstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Cardiac Monitor for VA ECMO Pediatric and Neonatal Patients
SBC: TRANSONIC SYSTEMS, INC. Topic: NHLBIPROJECT SUMMARY ABSTRACT Venoarterial Extracorporeal Membrane OxygenationVA ECMOis a way to provide cardiac and pulmonary support to patients without other alternativesThis form of life support is vital to pediatric and neonatal patientsAs with any life supportthere are serious complications that occurThese complications including bleedingthrombosisand infection become more frequent the longer a p ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
High Throughput CRISPR/Cas9 cell line generation using the CellRaft Array
SBC: Cell Microsystems, Inc. Topic: 400Project SummaryGenome editing technologiessuch as CRISPR Casprovide a rapidand targeted means of both knocking out gene expression and knocking in gene modificationsSince our initial Phase I submissionthe utility of CRISPR technology has expanded beyond the generation of cell linesto forward genetic screeningin vivo manipulation of gene expression and even human therapeuticsPhase I efforts success ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
An Interactive, Patient-Specific Virtual Surgical Planning System for Upper Airway Obstruction Treatments
SBC: Kitware, Inc. Topic: NIBIBABSTRACTUpper airway surgery encompasses a group of procedures commonly used to treat upper airway obstructionincluding maxillomandibular advancementsurgery of the soft palatenasal surgerytongue reduction surgeryand correction of tracheal stenosisCurrent diagnosis and the subsequent decision making of these pathologies primarily rely on the clinical examination and objective measures such as acous ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Intratumoral immunotherapy with formulated resiquimod for metastatic melanoma
SBC: Curebiotech, Inc. Topic: 102PROJECT SUMMARYMalignant melanoma is one of the most aggressive types of skin cancercausing a largemajority of skincancer related deaths worldwideThe combination of antiPDand antiCTLAis FDA approved for metastatic melanoma and shows better efficacy than any single agentaloneUnfortunatelythe incidence of highgrade immunerelated adverse eventsirAEsdue toantiCTLAis approachingThere is a pressing clin ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
A High School Program for Preventing Prescription Drug Abuse
SBC: NATIONAL HEALTH PROMOTION ASSOCIATES, INC Topic: NIDAABSTRACT A High School Program for Preventing Prescription Drug Abuse This Fast Track SBIR proposal is designed to address the critical need for an effective primary prevention approach for prescription drug abusePDAan urgent public health crisis in the United StatesDeaths from prescription drug overdoses have more than tripled in the pastyearsand the abuse of prescription opioids has fueled a dra ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health