Award Data

The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

Circular RNAscircRNAsare a novel class of modified RNAs that are an abundant component of the epitranscriptomePutative functions of circRNAsinclude miRNA sequestrationRNA binding protein scaffoldingmRNA trappingand protein translation regulationDeregulation in one or more of these roles has been linked to several types of cancerOne well studied circRNAciRSis believed to act as a miRNAsponge and in ...

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, t ...

Abstract Significance: Donor tissue shortage remains a critical problem in lung transplantation. Recent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffolds. These scaffolds, created from the donor’s tissue, become functionalized after recellularization with a patient’s own cells. However, translation of whole-lun ...

7. PROJECT SUMMARY/ABSTRACT Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) is a way to provide cardiac and pulmonary support to patients without other alternatives. This form of life support is vital to pediatric and neonatal patients. As with any life support, there are serious complications that occur. These complications including bleeding, thrombosis, and infection become more freq ...

Project SummaryGenome editing technologies, such as CRISPR/Cas9 provide a rapid, and targeted means of both knocking out gene expression and knocking in gene modifications. Since our initial Phase I submission, the utility of CRISPR technology has expanded beyond the generation of cell lines, to forward genetic screening, in vivo manipulation of gene expression and even human therapeutics. Phase I ...

ABSTRACTUpper airway surgery encompasses a group of procedures commonly used to treat upper airway obstructionincluding maxillomandibular advancementsurgery of the soft palatenasal surgerytongue reduction surgeryand correction of tracheal stenosisCurrent diagnosis and the subsequent decision making of these pathologies primarily rely on the clinical examination and objective measures such as acous ...

PROJECT SUMMARY     Malignant melanoma is one of the most aggressive types of skin cancer, causing a large  majority of skin-­cancer related deaths worldwide. The combination of anti-­PD-­1 and anti-­CTLA-­4  is FDA approved for metastatic melanoma and shows better efficacy than any single agent  alone. Unfortunately, the incidence of high-­gr ...

ABSTRACT A High School Program for Preventing Prescription Drug Abuse This Fast-Track SBIR proposal is designed to address the critical need for an effective primary prevention approach for prescription drug abuse (PDA), an urgent public health crisis in the United States. Deaths from prescription drug overdoses have more than tripled in the past 15 years, and the abuse of prescription opioids has ...

PROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos;s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardia (CPVT) CPVT. There are no FDA-approved treatments for CPVT, a rare genetic disorder affecting 1/10,000 individuals, with typical onset in children 7-9 years of age a ...