Award Data

The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...

Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

Project SummaryDyad MedicalIncwill create intravascular Optical Coherence TomographyIVOCTsoftware for clinicallive time determination of stent apposition and for offline analysis of stent implantationEvery years of thousands of patients in the US are treated with intravascular stents creating an opportunity for both solutionsAlthough advancements such as drug eluting metal stents hinder restenosis ...

Project SummaryGenome editing technologiessuch as CRISPR Casprovide a rapidand targeted means of both knocking out gene expression and knocking in gene modificationsSince our initial Phase I submissionthe utility of CRISPR technology has expanded beyond the generation of cell linesto forward genetic screeningin vivo manipulation of gene expression and even human therapeuticsPhase I efforts success ...

PROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardiaCPVTCPVTThere are no FDA approved treatments for CPVTa rare genetic disorder affectingindividualswith typical onset in childrenyears of age and no reported difference ...

The goal of this project is to develop novel technology for predicting drug induced kidney injury such as caused by systemic antimicrobialsdiureticsanticancer agentsand anti inflammatory drugsDrugs cause approximatelypercent of communityand hospitalacquired episodes of acute renal failurebut the incidence in older adults may be as high aspercentA significant problem is that while there are many dr ...

While CAR T therapies have advanced in the clinicthere are still two specific issues using these breakthrough therapies for blood cancersDurable responses in patients are only atand Cytokine Release Syndrome occurs inof treated patientsThese limitationsfor a drug that costs as much as $may cost an additional $for treating adverse events leading to caution for many clinical centers to administer th ...

Low molecular weight heparinsLMWHsare partially depolymerized natural products of heparinwhich are isolated from porcine intestineA worldwide distribution of contaminated heparin inwas associated withdeaths in the USThis crisis revealed the vulnerability of the LMWH supply chainLMWHs are complex mixtureshaving average molecular masses ofDaltonscorresponding tosaccharide unitsThe efficient preparat ...