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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Bottom Feeder- A Highly Maneuverable Autonomous Underwater Vehicle

    SBC: Tridentis Advanced Marine Vehicles LLC            Topic: 822

    The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

    SBIR Phase II 2019 Department of CommerceNational Oceanic and Atmospheric Administration
  2. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Targeted Intraceptors for Macular Degeneration

    SBC: Iveena Delivery Systems, Inc.            Topic: NEI

    Project Summary Age related Macular DegenerationAMDis the leading cause of blindness in USIt affects overof the people by the ageAn estimatedmillion people are afflicted with AMD worldwideNeovascular orwetAMDwhich affectsof AMD patientsis a rapid form of the disease and progresses to blindness if left untreatedHistopathologicallythe disease involves lesions in the Bruchandapos s membrane and or re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions

    SBC: Baebies, Inc.            Topic: NICHD

    An estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Tuned stem cell extracellular vesicles are a novel chronic wound therapeutic

    SBC: Zen-Bio, Inc.            Topic: NIA

    Project Summary The elderly population is rapidly increasing worldwide and those overyears old are expected to compriseof the total population byThese demographic changes will focus healthcare needs on those conditions more prevalent in the elderlyChronic woundssuch as venous leg ulcerspressure ulcers and diabetic ulcers are over represented in the elderly population and even now present a signifi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Co-culture cassette for anaerobes and primary human intestinal epithelium

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project SummaryThe human colon is a remarkable organplaying critical roles in drug uptake and metabolism as well as harboring thetrillion microbial cells of the microbiomewhich itself has multiple impacts on human healthFor these reasonsthere is a widespread need in academia and the biotechnology marketplace for in vitro studies of human colon physiology and the interaction between colon tissue an ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Increased sensitivity of minimal residual disease monitoring using peripheral blood in pediatric patients with acute lymphoblastic leukemia

    SBC: BIOFLUIDICA, INC.            Topic: 102

    Abstract Acute lymphoblastic leukemiaALLis the most common malignant disease in childhood and accounts for approximatelyof all cancers diagnosed before the age ofyearsThe primary cause of death for ALL patients is disease relapseThereforemonitoring for minimal residual diseaseMRDis considered the most powerful predictor of outcome in acute leukemiasincluding B type acute lymphoblastic leukemiaB AL ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Localized Delivery of Sirolimus to Hemodialysis Vascular Access Grafts

    SBC: Cylerus, Inc.            Topic: NIA

    Abstract CylerusIncis developing an implantablesirolimus eluting cuff and reservoir systemcombined with a clinically approved drug pumpto solve the difficult problem of prosthetic vascular graft failureVascular grafts constructed using either synthetic polymers or native veins are widely used in vascular surgeryThe most common indications for these grafts areHemodialysis accessin which blood acces ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: 400

    Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescenceThese affiliations often arise when socially marginalized youth self aggregate and reinforce alcohol use and other deviant activityi edeviant peer clusteringEven though the field has developed efficacious school based prevention programsprogram effects are generally smalland these programs can be ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Software for predicting a drug's potential to cause acute kidney injury

    SBC: DILIsym Services, Inc.            Topic: 400

    The goal of this project is to develop novel technology for predicting drug-induced kidney injury such as caused by systemic antimicrobials, diuretics, anticancer agents, and anti-inflammatory drugs. Drugs cause approximately 20 percent of community- and hospital- acquired episodes of acute renal failure, but the incidence in older adults may be as high as 60 percent. A significant problem is that ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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