Award Data

NOAA is pursuing sustained, in-situ sensing technology to support improved atmospheric modeling of the upper ocean boundary environment, including the air-sea interface, during turbulent storms. Improved atmospheric modeling in this critical region will lead to better forecasting and support NOAA's mandate to protect property and save lives. Small, unmanned aircraft, equipped with atmospheric sens ...

The S‐100 specification is a new geospatial standard for hydrographic data, that is presently under development by the International Hydrographic Organization (IHO). Once the S‐100 based products and services are fully developed by the IHO, current datasets will be scheduled for obsolescence, and the Hydrographic Offices (HOs) will no longer produce them. Companies offering e‐navigation solu ...

In this Phase II effort, PEMDAS Technologies and Innovations (PEMDAS), in collaboration with subcontractor Westover Studios, proposes to develop a functional prototype of the Weather “Action Chain” Enabler (ACE) application using the technologies identified, knowledge gained, and preliminary design conceived during the Phase I effort. As designed, the Weather ACE application will be a non-intr ...

The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...

Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

Project SummaryGenome editing technologiessuch as CRISPR Casprovide a rapidand targeted means of both knocking out gene expression and knocking in gene modificationsSince our initial Phase I submissionthe utility of CRISPR technology has expanded beyond the generation of cell linesto forward genetic screeningin vivo manipulation of gene expression and even human therapeuticsPhase I efforts success ...

Ventilator associated pneumoniaVAPoccurshoursor morefollowing endotracheal intubation and accounts for half of all cases of hospital acquired pneumoniaCDC reports and many clinical studies point to a critical need for preventing ventilator associated infections rather than fighting an often losing battle against acquired infectionResponding to this unmet needWynnVision LLCWVwill leverage strong pr ...

PROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardiaCPVTCPVTThere are no FDA approved treatments for CPVTa rare genetic disorder affectingindividualswith typical onset in childrenyears of age and no reported difference ...