Award Data

Animal-borne electronic instruments (tags) are critical tools for monitoring the behavior and ecology of cetaceans, providing data needed for managing their populations and mitigating the threats they face. Although remote-deployment of tags onto cetaceans that cannot be captured has provided valuable data, attachment durations have been frustratingly short and variable. Our Phase II goal is to de ...

The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

Humanriver blindnessis caused by a filarial parasite and is a serious neglected tropical disease contributing to blindnessskin diseaseand chronic disability in the developing worldEstimates from the Global Burden of Disease Studyindicate thatmillion cases of onchocerciasisleading tomillion cases of vision impairmentoccur worldwide every yearThe goal of this project is to develop a safe and effecti ...

CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...

Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

Project SummaryGenome editing technologiessuch as CRISPR Casprovide a rapidand targeted means of both knocking out gene expression and knocking in gene modificationsSince our initial Phase I submissionthe utility of CRISPR technology has expanded beyond the generation of cell linesto forward genetic screeningin vivo manipulation of gene expression and even human therapeuticsPhase I efforts success ...

As the population continues to agedegenerative ocular diseases become increasingly common and create a tremendous burden on the health care systemAge related macular degenerationAMDrepresents a significant problem withmillion patients at risk to progress to severe vision loss in the U Salone and the prevalence of AMD is expected to double byThe dry and wet forms of the disease significantly impair ...

SUMMARY Millions of blood samples are tested annually to establish blood type compatibility between blood donors and transfusion recipientsHowevercurrent testing methods are encumbered by the need for large blood samplestransportation to centralized laboratoriestime to centrifuge and perform testingspecialized reagentsand technical training needsplacing a costly burden on the medical systemIn part ...

PROJECT ABSTRACT Prostate Specific Membrane AntigenPSMAis an ideal tumor biomarker as it is expressed on andgtof all prostate cancers and expression increases as the cancer progressesCancer Targeted TechnologyCTThas developed a unique phosphoramidate based scaffold that binds irreversibly to PSMA leading to andgtrapid internalization and selective accumulation in tumor cellsWith previous SBIR gran ...