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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Bottom Feeder- A Highly Maneuverable Autonomous Underwater Vehicle
SBC: Tridentis Advanced Marine Vehicles LLC Topic: 822The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...
SBIR Phase II 2019 Department of CommerceNational Oceanic and Atmospheric Administration -
Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation
SBC: Brain Electrophysiology Laboratory Company, LLC Topic: 101This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, t ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Whole-organ bioreactor with integrated nondestructive 3D molecular imaging
SBC: Sonovol, Inc. Topic: NHLBIAbstract Significance: Donor tissue shortage remains a critical problem in lung transplantation. Recent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffolds. These scaffolds, created from the donor’s tissue, become functionalized after recellularization with a patient’s own cells. However, translation of whole-lun ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Passive Exoskeleton for Children with Neuromuscular Disorders
SBC: RUSH RIVER RESEARCH CORP Topic: NICHDProject Summary/Abstract Rush River Research (RRR) Corporation proposes to develop and commercialize a novel passive exoskeleton that helps young children with very little residual strength to use their arms. The proposed orthosis could help the over 500,000 children with many different neuromuscular disorders including muscular dystrophy, spinal muscular atrophy, cerebral palsy, arthrogryposis mu ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
High Throughput CRISPR/Cas9 cell line generation using the CellRaft Array
SBC: CELL MICROSYSTEMS INC Topic: 400Project SummaryGenome editing technologies, such as CRISPR/Cas9 provide a rapid, and targeted means of both knocking out gene expression and knocking in gene modifications. Since our initial Phase I submission, the utility of CRISPR technology has expanded beyond the generation of cell lines, to forward genetic screening, in vivo manipulation of gene expression and even human therapeutics. Phase I ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
HLS-Cardiac Safety AI Trained Human Heart and Micro Heart Model
SBC: Invivosciences, Inc. Topic: NHLBIHLS17-12. The US FDA is considering to establish a new cardiac safety assessment approachdefined by a new paradigm called, “Comprehensive in vitro Proarrhythmia Assay (CIPA)”. The CIPA will 1) assess drug effects on each cardiac ion channel type individually using a high- throughput assay ion channel assays, 2) compute net effect on repolarization and risks fortorsade pointes (TdP) using a mat ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Development of Novel Compounds for Treatment of Heart Arrhythmias in CPVT
SBC: Elex Biotech, Inc Topic: NHLBIPROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos;s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardia (CPVT) CPVT. There are no FDA-approved treatments for CPVT, a rare genetic disorder affecting 1/10,000 individuals, with typical onset in children 7-9 years of age a ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Software for predicting a drug's potential to cause acute kidney injury
SBC: DILIsym Services, Inc. Topic: 400The goal of this project is to develop novel technology for predicting drug-induced kidney injury such as caused by systemic antimicrobials, diuretics, anticancer agents, and anti-inflammatory drugs. Drugs cause approximately 20 percent of community- and hospital- acquired episodes of acute renal failure, but the incidence in older adults may be as high as 60 percent. A significant problem is that ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies
SBC: ISOPLEXIS CORPORATION Topic: 102While CAR-T therapies have advanced in the clinic, there are still two specific issues using these breakthrough therapies for blood cancers: Durable responses in patients are only at 30-50% and Cytokine Release Syndrome occurs in 60-90% of treated patients. These limitations, for a drug that costs as much as $500,000, may cost an additional $250,000+ for treating adverse events leading to caution ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Scalable post-assembly editing software for finishing and annotating personal genomes
SBC: DNASTAR, INC. Topic: 300We are entering a new era of personal genomics where an individualandapos;s genome sequence will be used to identify disease susceptibility, improve diagnosis and better treat illnesses as well as be combined across cohorts and populations to identify new biomarkers and causal mutations underlying any phenotype. Despite the tremendous success of mapping short read next-generation sequencing (NGS) ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health