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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Co-culture cassette for anaerobes and primary human intestinal epithelium

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project SummaryThe human colon is a remarkable organplaying critical roles in drug uptake and metabolism as well as harboring thetrillion microbial cells of the microbiomewhich itself has multiple impacts on human healthFor these reasonsthere is a widespread need in academia and the biotechnology marketplace for in vitro studies of human colon physiology and the interaction between colon tissue an ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: 400

    Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescenceThese affiliations often arise when socially marginalized youth self aggregate and reinforce alcohol use and other deviant activityi edeviant peer clusteringEven though the field has developed efficacious school based prevention programsprogram effects are generally smalland these programs can be ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Increased sensitivity of minimal residual disease monitoring using peripheral blood in pediatric patients with acute lymphoblastic leukemia

    SBC: BIOFLUIDICA, INC.            Topic: 102

    Abstract Acute lymphoblastic leukemiaALLis the most common malignant disease in childhood and accounts for approximatelyof all cancers diagnosed before the age ofyearsThe primary cause of death for ALL patients is disease relapseThereforemonitoring for minimal residual diseaseMRDis considered the most powerful predictor of outcome in acute leukemiasincluding B type acute lymphoblastic leukemiaB AL ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions

    SBC: Baebies, Inc.            Topic: NICHD

    An estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Selection and preclinical development of a bacteria-targeting, non-antibiotic lead candidate to improve cancer chemotherapy outcomes

    SBC: SYMBERIX, INC.            Topic: 102

    The long term objective of this project is a therapeutic adjunct to prevent chemotherapy induced diarrheaCIDbased on a completely new mechanism of action targeting enteric bacteriaThis Fast Track SBIR proposal outlines the strategy for selecting a lead development candidate to be evaluated in investigational new drugINDenabling studies to support a first in human trialThe focus of this project is ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Multiplex Platform for Point-of-Care Newborn Screening of Hyperbilirubinemia

    SBC: Baebies, Inc.            Topic: NICHD

    ABSTRACT Multiplex Platform for Point of Care Newborn Screening of HyperbilirubinemiaSBIR Phase IIBHyperbilirubinemiajaundiceaffects more than half of all newborns and is typically benign if identified and treated promptlyWithout proper treatmenthigh bilirubin leads to serious neurological dysfunction including neuro motorauditoryspeechcognitionand language disturbancesRapid identification of newb ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Whole-organ bioreactor with integrated nondestructive 3D molecular imaging

    SBC: Sonovol, Inc.            Topic: NHLBI

    Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: IsoPlexis            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Novel assay to monitor Tacrolimus levels at the point of care

    SBC: AFFINERGY, LLC            Topic: NIAID

    SUMMARY ABSTRACT Inoverorgan transplants were performed in the United Statesan increase ofover the pastyearsOrgan transplantation requires lifelong immunosuppression to prevent rejection of the transplantTacrolimusa macrolide antibioticis one of the most effective immunosuppressantswith andgtof solid organ transplant recipients receiving it as part of their maintenance immunosuppressionTacrolimus ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Culturally Responsive Stress Reduction: A Mobile Mindfulness Application toSupport Health Promotion for African Americans

    SBC: IRIS MEDIA INC            Topic: 102

    ABSTRACTThe proposed interventionCulturally Responsible Stress ReductionA Mobile Mindfulness Application to Support Health Promotion for African AmericansCRSRis designed to encourage the use of mindfulness to mitigate the disproportionate amount of stress related health disparities facing African AmericansCurrent mindfulness approaches have been unsuccessful in engaging this populationThis proposa ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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