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Award Data
The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.
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A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular Dystrophies
SBC: Baebies, Inc. Topic: NICHDCongenital genetic abnormalities are a leading cause of childhood mortality and morbidity. While routine newborn screening (NBS) has dramatically improved health outcomes, many congenital disorders such as Duchenne muscular dystrophy (DMD) and other congenital muscular dystrophies (CMD) are not currently detected by routine NBS. Presymptomatic identification through NBS is critical to facilitate e ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions
SBC: Baebies, Inc. Topic: NICHDAn estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies
SBC: IsoPlexis Topic: 102While CAR-T therapies have advanced in the clinic, there are still two specific issues using these breakthrough therapies for blood cancers: Durable responses in patients are only at 30-50% and Cytokine Release Syndrome occurs in 60-90% of treated patients. These limitations, for a drug that costs as much as $500,000, may cost an additional $250,000+ for treating adverse events leading to caution ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
SBC: Oregon Research Behavioral Intervention Strategies, INC Topic: 400Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescenceThese affiliations often arise when socially marginalized youth self aggregate and reinforce alcohol use and other deviant activityi edeviant peer clusteringEven though the field has developed efficacious school based prevention programsprogram effects are generally smalland these programs can be ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Bottom Feeder- A Highly Maneuverable Autonomous Underwater Vehicle
SBC: Tridentis Advanced Marine Vehicles LLC Topic: 822The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...
SBIR Phase II 2019 Department of CommerceNational Oceanic and Atmospheric Administration -
BurntOut: Role-Play Simulation for Building Medical Student Resiliency
SBC: Clinical Tools, Inc Topic: 400PROJECT DESCRIPTIONBurntOutRole Play Simulation for Building Medical Student Resiliency Medical student and physician burnout rates are highRates correlate with alcohol and other substance use problemsand negatively impact patient careThis project will create aD simulation BurntOutRolePlay Simulation for medical students to practice and respond to stressful situationsenhance copingand develop ways ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Chromatography-Free Antibody Purification by Affinity-Phase Separation
SBC: Isolere Bio, Inc Topic: 400Abstract The objective of this NIH Phase II SBIR proposal is to demonstrate the commercial feasibility of IsoTag™, a novel cost-effective method to purify monoclonal antibodies (mAbs) that eliminates the need for Protein A (PrA) chromatography. This objective will be achieved by using a recombinant fusion comprised of a stimulus responsive elastin-like polypeptide (ELP) that can undergo a revers ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Co-culture cassette for anaerobes and primary human intestinal epithelium
SBC: Altis Biosystems, Inc. Topic: 300Project SummaryThe human colon is a remarkable organplaying critical roles in drug uptake and metabolism as well as harboring thetrillion microbial cells of the microbiomewhich itself has multiple impacts on human healthFor these reasonsthere is a widespread need in academia and the biotechnology marketplace for in vitro studies of human colon physiology and the interaction between colon tissue an ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Cross-Protective Multivalent Vaccine for Tick-Borne Flaviviruses
SBC: Hawaii Biotech, Inc. Topic: NIAIDProject Summary/AbstractThe NIH/NIAID 2017 Strategic Plan is specifically directed at promoting research that can provide solutions to mitigate the threat posed by emerging and re-emerging diseases. The tick-borne flavivirus (TBFV) group includes a number of important human pathogens that result in serious neurological or hemorrhagic diseases that are either Category B or C priority pathogens. The ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Culturally Responsive Stress Reduction: A Mobile Mindfulness Application toSupport Health Promotion for African Americans
SBC: IRIS MEDIA INC Topic: 102ABSTRACTThe proposed intervention, Culturally Responsible Stress Reduction: A Mobile Mindfulness Application to Support Health Promotion for African Americans (CRSR), is designed to encourage the use of mindfulness to mitigate the disproportionate amount of stress-related health disparities facing African Americans. Current mindfulness approaches have been unsuccessful in engaging this population. ...
SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health