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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

    SBC: Brain Electrophysiology Laboratory Company, LLC            Topic: 101

    This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Whole-organ bioreactor with integrated nondestructive 3D molecular imaging

    SBC: Sonovol, Inc.            Topic: NHLBI

    Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. High Throughput CRISPR/Cas9 cell line generation using the CellRaft Array

    SBC: Cell Microsystems, Inc.            Topic: 400

    Project SummaryGenome editing technologiessuch as CRISPR Casprovide a rapidand targeted means of both knocking out gene expression and knocking in gene modificationsSince our initial Phase I submissionthe utility of CRISPR technology has expanded beyond the generation of cell linesto forward genetic screeningin vivo manipulation of gene expression and even human therapeuticsPhase I efforts success ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Novel Compounds for Treatment of Heart Arrhythmias in CPVT

    SBC: Elex Biotech, Inc            Topic: NHLBI

    PROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardiaCPVTCPVTThere are no FDA approved treatments for CPVTa rare genetic disorder affectingindividualswith typical onset in childrenyears of age and no reported difference ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Software for predicting a drug's potential to cause acute kidney injury

    SBC: DILIsym Services, Inc.            Topic: 400

    The goal of this project is to develop novel technology for predicting drug induced kidney injury such as caused by systemic antimicrobialsdiureticsanticancer agentsand anti inflammatory drugsDrugs cause approximatelypercent of communityand hospitalacquired episodes of acute renal failurebut the incidence in older adults may be as high aspercentA significant problem is that while there are many dr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies

    SBC: IsoPlexis            Topic: NCI

    While CAR T therapies have advanced in the clinicthere are still two specific issues using these breakthrough therapies for blood cancersDurable responses in patients are only atand Cytokine Release Syndrome occurs inof treated patientsThese limitationsfor a drug that costs as much as $may cost an additional $for treating adverse events leading to caution for many clinical centers to administer th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a New Carbohydrate-based Anticoagulant Drug

    SBC: Glycan Therapeutics LLC            Topic: NHLBI

    Low molecular weight heparinsLMWHsare partially depolymerized natural products of heparinwhich are isolated from porcine intestineA worldwide distribution of contaminated heparin inwas associated withdeaths in the USThis crisis revealed the vulnerability of the LMWH supply chainLMWHs are complex mixtureshaving average molecular masses ofDaltonscorresponding tosaccharide unitsThe efficient preparat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Low cost retinal optical coherence tomography for point of care use

    SBC: Lumedica, Inc            Topic: NEI

    The objective of this research is to create a clinical prototype of a new optical coherence tomographyOCTsystem suitable for diagnostic retinal imaging at the point of careThe target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systemsBy breaking the $system barrier we will provide an in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Mindfulness Mobile App to Reduce Adolescent Substance Use

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: NIDA

    Abstract Adolescents in the juvenile justice system demonstrate very high rates of tobaccoalcoholand other drug useATODwith rates that are estimated to be three times higher than non justice involved youthSubstanceabusing youthespecially those who are involved in the juvenile justice systemare at higher risk than nonusers for mental health problemsincluding depressionconduct problemspersonality di ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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