Award Data

ABSTRACT Improving Anticoagulation Monitoring in Pediatric Patients: Use of a Microfluidic Platform to Test Low Volume Blood Samples Obtained by Heel-Stick Collection Children treated for congenital heart defects or other disorders of hypercoagulation are prescribed unfractionated heparin (UFH) or low molecular weight heparin (LMWH) throughout surgical treatment; they may be prescribed heparin for ...

This Phase II SBIR project builds upon previous research to develop and evaluate the efficacy of an online mindfulness education program for youth with 22q11DS, called the Aware Program. The program is an innovative and developmentally appropriate program that includes brief online modules designed to teach teens about mindfulness and mindfulness practices, as well as provide them with examples of ...

ABSTRACT: Since 1982, through four versions, the Diagnostic Interview Schedule for Children (DISC) has served as a gold-standard assessment for diagnosing behavioral, DSM disorders in children aged 6 to 17. As a computer- assisted lay interview (LI) and more recently in a self-report (SR) format, the DISC-IV has been reliable, comparatively inexpensive to administer, and was cited in over 805 peer ...

ABSTRACT: Car crashes are the leading cause of death among adolescents and young adults. Impaired driving, including distracted, drugged, drowsy, and drunk driving, is a common cause of car crashes and an important public health and safety issue. Drunk driving has decreased among teens, but is still commonly reported and a cause for concern. Drugged driving, especially, is a critical and growing p ...

ABSTRACT Healthcare-associated infections (HAI) are the single largest preventable medical cost in terms of both economic and humanitarian cost. The major significance of this problem is reflected in the $35-billion annual expenditure made for healthcare associated infections in the medical community. Due to the large number of procedures done each year, endoscopes are associated with more HAI out ...

Project Summary Respiratory Syncytial Virus (RSV) is the leading cause of viral death in infants and young children, and a major cause of respiratory illness in immune compromised adults and the elderly. Unfortunately, there is currently no vaccine or effective therapy available for RSV. Synagis, a monthly intramuscular injection of the monoclonal antibody (mAb) palivizumab, is the only FDA-approv ...

ABSTRACT Evaluating the biological activity of protein kinase inhibitors (PKI) is one of the most challenging problems of drug development. Here, we propose a new evaluation approach (the ATTAKIN™) in which we infer PKI bioactivities from responses of cellular signaling. As a readout, we assess the activity of transcription factors that connect the signaling pathways to regulated genes. In preli ...

Project Summary Translational Imaging Innovations (TII) is creating an integrated platform for the collection, curation, analysis and sharing of ocular images and data. Our Integrated Translational Imaging™ platform integrates an electronic research workflow management system with an image repository, or data lake, and provides methods for controlling the flow of images and data to a visualizati ...

Project DescriptionApproximately one out of three 2- to 5-year-old children in the United States has experienced caries (tooth decay). The American Academy of Pediatric Dentistry and American Academy of Pediatrics provide recommendations for preventive strategies, and recognize that infant, toddler and early childhood oral health is one of the foundations upon which preventive education and dental ...

ABSTRACT Feasibility and validation of an integrated newborn screening algorithm with targeted Next GenerationSequencing (tNGS) technology as part of a 2nd-tier test for Pompe and MPS I Newborn screening (NBS) utilizes high throughput primary (1st-tier) screening assays paired with referral and clinical follow-up testing to identify babies who are affected with certain inherited disorders. Where n ...