Award Data

DESCRIPTION (provided by applicant): Probably the most versatile assay for genomic scale research is the high-density microarray. Microarray analysis has the potential for uncovering the complex behavior of gene expression. Microarray trends are becoming established which includes higher throughput and a need to analyze pg quantities of mRNA. This proposal is focused on one aspect of microarray te ...

Because it is an energetic pure beta emitter with a half-life on the scale of days (64.1 hr) 90Y is seeing increasing interest as an isotope for use as a radiation source for radioimmunotherapy (RIT). Current processes for obtaining 90Y involve extracting and purifying the 90Y produced by the decay of 90Sr in solution using a liquid-liquid extraction process. The isotope is produced at a centraliz ...

In May 1999, a Licensing Agreement between Zonagen, Inc. and the NICHD was finalized to develop new 19-substituted-norprogestins. If the new antiprogestins behave as tissue-specific modulators in the manner of selective estrogen response modulators (SERMs), they may be recognized as an analogous class of drugs, i.e., as SPRMs. Such SPRMs discovered by NICHD and realized as drugs through this SBIR, ...

Acetaminophen and NSAIDs have been used routinely for treatment of pain and/or fever. This dual action is sometimes contraindicated. In many instances, pain needs to be controlled without masking symptomatic fever (e.g., during the postoperative period). These drugs can cause hepatotoxicity, particularly after ingestion of large doses or from chronic use (especially when liver function has been co ...

DESCRIPTION (provided by applicant): Many reported risks and hazards in hemodialysis are associated with water quality, including pyrogenic contamination. The typical patient on dialysis is exposed to between 30 to 40 times the amount of water to which a member of the general population is exposed. Thus, the quality of hemodialysis water is obviousl ...

DESCRIPTION (provided by applicant): In Phase I Kestrel Corporation developed and demonstrated a retinal imaging system that combines multispectral imaging techniques with adaptive optics and image deconvolution to provide high resolution less than (

The National Long Term Care Survey (NLTCS) contains unique longitudinal microdata on persons aged 65 and older who are chronically impaired. The public-use files distributed by Duke University. Center for Demographic Studies (CDS), have the additional benefit that they are linked to Medicare data available to. authorized researchers from the Health Care financing Administration (HCFA) and include ...

DESCRIPTION (provided by applicant): Insurance providers spend millions of dollars on prosthetics and pressure reducing modalities for diabetes-related wound care; however, no scientific data exists on shear (friction) and scarce data on pressure reduction. Presently, no commercially available removable cast walker reduces shear. Salix Medical's (patent pending) removable cast walker (ACE walker) ...

DESCRIPTION (provided by applicant): The overall goal is to develop a "Cells-to-Signal" assay in which a single reagent is added to cells and then used directly for the detection of a specific RNA sequence. The Cells-to-Signal assay will be especially useful by pharmaceutical companies in drug discovery for the high throughput screening of multiple compounds for their effects on the transcription ...

DESCRIPTION (provided by applicant): In the last few years an extraordinary emphasis has been placed on the design and use of PET cameras for small animal studies, for example, to aid in the development of human gene therapies by imaging transgenic animals such as mice. Although, such techniques have an extraordinary potential for both clinical and basic biomedical science applications, its full r ...