Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. MULTIRESOLUTION AUTOFOCUSING FOR AUTOMATED CYTOGENETICS

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    The goal of this project is to develop innovative digital microscope autofocusing techniques for automated cytogenetics applications. We propose a novel multi-resolution image analysis approach to focus measurement and detection, based on the recently developed mathematical theory of wavelet transform. In comparison to currently available single-resolution techniques, the proposed method overcom ...

    SBIR Phase I 2002 Department of Health and Human Services
  2. IMPROVED IMAGING FOR PRECISE CRYTPIC ANOMALY DETECTION

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This project will further develop automated instrumentation and image analysis techniques to detect cryptic chromosomal rearrangements, which are difficult to detect by conventional cytogenetics. It combines two innovative FISH probes: "SubTelomeric" (STFISH) and "Multiplex" (MFISH), with sophisticated image analysis, ...

    SBIR Phase I 2002 Department of Health and Human Services
  3. IMPROVED IMAGING FOR PRECISE CRYTPIC ANOMALY DETECTION

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This project will further develop automated instrumentation and image analysis techniques to detect cryptic chromosomal rearrangements, which are difficult to detect by conventional cytogenetics. It combines two innovative FISH probes: "SubTelomeric" (STFISH) and "Multiplex" (MFISH), with sophisticated image analysis, ...

    SBIR Phase II 2002 Department of Health and Human Services
  4. CO-AMPLIFIED RNAS FOR COMPARITIVE MICROARRAY ANALYSIS

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    Ambion, Inc. proposes to develop methods and reagents that will make it possible to compare the expression profiles of small RNA samples (

    SBIR Phase I 2002 Department of Health and Human Services
  5. SIRNA DESIGN, PRODUCTION AND DELIVERY

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): RNA interference is a new and powerful research tool that can be used to down regulate or knock out a specific gene or genes in a variety of cell types and organisms. Currently this technology is being used to study gene function, but may one day be used for human therapeutics. The RNAi phenomenon was only recently demonstrated to be present in mammalian cells ...

    SBIR Phase I 2002 Department of Health and Human Services
  6. MULTI-SAMPLE COMPARATIVE RT-PCR

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    Ambion, Inc. proposes to adapt its Comparative RT-PCR procedure to accommodate the comparative analysis of single transcripts across one hundred RNA samples. The proposed procedure involves reverse transcribing a collection of RNA samples using primers with identical anchored oligodT and PCR primer binding sites but intervening hybridization domains that are unique to each sample. Equal amounts o ...

    SBIR Phase I 2002 Department of Health and Human Services
  7. ADVANCING RNA AMPLIFICATION TECHNOLOGIES FOR MICROARRAYS

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Probably the most versatile assay for genomic scale research is the high-density microarray. Microarray analysis has the potential for uncovering the complex behavior of gene expression. Microarray trends are becoming established which includes higher throughput and a need to analyze pg quantities of mRNA. This proposal is focused on one aspect of microarray te ...

    SBIR Phase I 2002 Department of Health and Human Services
  8. ENZYMATIC TOOLS FOR DEGRADING TISSUE AND PRESERVING RNA

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Intact RNA is an obligate starting material for expression profiling technologies that can link specific molecular events with disease phenotypes. RNA isolations from tissue currently require invasive mechanical force to disrupt the cellular architecture. Such mechanical approaches are tedious and potentially inefficient. They also expose the operator to possib ...

    SBIR Phase I 2002 Department of Health and Human Services
  9. INNOVATIVE TECHNOLOGY FOR IN VITRO EVOLUTION OF PROTEINS

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to develop a powerful in vitro protein engineering platform that will allow selection or screening of very large numbers of protein variants that is at least 100 -1000 times more cost effective than current 96 well plate based approaches. This strategy is based on generating cell wall bounded micro-compartments, which c ...

    SBIR Phase I 2002 Department of Health and Human Services
  10. ADVANCING RNA AMPLIFICATION TECHNOLOGIES FOR MICROARRAYS

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Probably the most versatile assay for genomic scale research is the high-density microarray. Microarray analysis has the potential for uncovering the complex behavior of gene expression. Microarray trends are becoming established which includes higher throughput and a need to analyze pg quantities of mRNA. This proposal is focused on one aspect of microarray te ...

    SBIR Phase II 2002 Department of Health and Human Services
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