Award Data

DESCRIPTION (provided by applicant): Prostate cancer continues to be a significant health problem, both domestically and worldwide. Numerous studies have demonstrated the efficacy and safety of transperineal prostate brachytherapy in the therapy of prostate cancer. The success of brachytherapy chiefly depends on our ability to intra-operatively tailor the radiation dose to the patient's individual ...

DESCRIPTION (provided by applicant): Neural prosthetic devices are artificial extensions to the body that restore or supplement nervous system function that was lost during disease or injury. Particular success has been realized in the cochlear prostheses development. In contemporary cochlear implants, however, the injected electric current is spread widely along the scala tympani and across turns ...

DESCRIPTION (provided by applicant): Development of an optical brain/nerve stimulator Abstract In a novel technological breakthrough in neural stimulation, our collaborators at Vanderbilt University have developed a new modality that uses low intensity pulsed infrared laser light instead of electrical energy to elicit compound nerve and muscle potentials. Optical stimulation can induce spatially p ...

DESCRIPTION (provided by applicant): Aegis BioSciences has developed a new and versatile class of anionic, nanostructured hydrogel materials with promising applications in wound care, anti-thrombogenic coatings, and drug delivery. These multi-phase block copolymers are derived from inexpensive, commercially available materials which are subsequently sulfonated. Indeed, growing interest in these ma ...

DESCRIPTION (provided by applicant): It is estimated that 2.5 million people in the United States have chronic venous ulcers. In the developed world, at least 0.1% of the adult population is likely to experience venous ulceration at some time. With the overall prevalence, estimated to be between 1.1 and 3.0 incidents per one thousand individuals, occurrence of venous ulcers increases exponentially ...

DESCRIPTION (provided by applicant): Elevated intracranial pressure (ICP) is associated with a number of serious neurological conditions. Its successful management yields improved outcome for patients, yet ICP can only be measured by placing a device within the cranium through a hole in the skull (yielding invasive ICP, or ilCP), a procedure associated with significant risks and requiring a neuros ...

DESCRIPTION (provided by applicant): Locating fluorescently-tagged cells in whole organisms is important to the development of gene therapy, stem cell therapy delivery methods, and for drug research. This project will develop an intelligent microtome to identify fluorescently labeled cells in whole mice and to collect those cells in thin sections. During Phase I, a small-mammal cryomicrotome with ...

DESCRIPTION (provided by applicant): The goals of this project are to develop, evaluate, and disseminate an Internet (web) application, Moderate Drinking (MD). MD will use a behavioral self-control training (BSCT) protocol that helps drinkers learn skills to either moderate their drinking or to abstain. The target population is members of the self-help organization, Moderation Management (MM) and ...

DESCRIPTION (provided by applicant): Dissemination of evidence-based therapies remains a high priority at NIDA. A number of barriers limit accessibility to evidence-based therapies in routine clinical settings. Substance use disorders (SUDs) co-occurring with borderline personality disorder (BPD) pose serious and complex public health problems. Dialectical Behavior Therapy for Substance Abusers (D ...

DESCRIPTION (provided by applicant): Interpersonal Psychotherapy (IPT) is one of the most thoroughly validated psychosocial treatments for depression. Dissemination of IPT, however, has been hindered by lack of trainers and didactic materials. Though several excellent textbooks regarding IPT are available [10, 24], there are no other standardized educational materials or videotapes demonstrating s ...