Award Data

DESCRIPTION (provided by applicant): The proposed research project supports the investigation and development of technology to provide better access to speech recognition-based systems for individuals with speech impairments due to dysarthria or other medical condition. With current automatic speech recognition software, typical error rates are unnacceptably high for speakers whose speech differs ...

DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a polymer stentgraft for the treatment of cerebral aneurysms. The stentgraft is formed from coaxial inner and outer tubes of elastomeric polymer, with the gap between the tubes filled by an uncured liquid adhesive. The device is deployed over a balloon catheter. After placement in the desired location, polymerization o ...

A health-based serial radio program for commercial radio

DESCRIPTION (provided by applicant): The use of dietary supplements has become increasingly popular in the US, and these supplements are not subject to stringent pre-marketing testing or post-marketing surveillance. More than a third of American adults report using some form of CAM, with total visits to CAM providers each year now exceeding those to primary-care physicians. An estimated 15 million ...

DESCRIPTION (provided by applicant): The long term objectives of this proposal are aimed at the development of new composition(s) to be used for the prophylactic treatment/prevention of poison ivy contact dermatitis in sensitive individuals. Poison ivy/poison oak and another related species poison sumac are the main cause of occupational hazards for outdoor workers in the United States. Most of th ...

DESCRIPTION (provided by applicant): Hemophilia A is a bleeding disorder caused by mutations within the factor VIII (fVIII) gene that result in a deficiency of circulating fVIII activity. Current treatment for hemophilia relies on infusion of plasma-derived or recombinant fVIII to restore circulating fVIII activity. This form of therapy is 1) expensive, 2) hard to maintain due to the frequency and ...

DESCRIPTION (provided by applicant): DNA cloning, also known as gene splicing or recombinant DNA technology, is crucial for all aspects of biomedical and biotechnology research. For example, DNA cloning has been of central importance for sequencing the human genome, generating safer vaccines, identifying genes involved in cancer and many other diseases, and producing therapeutic drugs such as insu ...

DESCRIPTION (provided by applicant): This Phase I SBIR proposal will yield a prototype of a fully synthetic simulation-based training system to teach proper assessment, diagnosis and treatment of incipient lesions and true dental caries. IDEA International, Inc., in conjunction with the Harvard Dental School and others with experience in the simulation and virtual environment business, will create ...

DESCRIPTION (provided by applicant): The objective of this project is to demonstrate a methodology for improving the quality of retinal images taken with standard fundus camera. Kestrel has developed a family of algorithms that perform image retinal enhancement through the implementation of a methods that are inspired from human visual system mechanisms. Standard retinal images often suffer from i ...

DESCRIPTION (provided by applicant): The broad objective of this proposed research is to determine the effect of sodium thiosulfate on kidney stone formation. The drug will initially be studied in a rat model of nephrolithiasis and if the drug is shown to reduce risk of new stone formation we will study the drug in patients with nephrolithiasis. The long term goal is to bring a new therapy for kid ...