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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Quantitative C-arm Fluoroscopy- Prostate Brachytherapy

    SBC: BURDETTE MEDICAL SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Prostate cancer continues to be a significant health problem, both domestically and worldwide. Numerous studies have demonstrated the efficacy and safety of transperineal prostate brachytherapy in the therapy of prostate cancer. The success of brachytherapy chiefly depends on our ability to intra-operatively tailor the radiation dose to the patient's individual ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  2. C-arm Fluoroscopy for Prostate Brachytherapy

    SBC: BURDETTE MEDICAL SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A technique is proposed for the development of an intraoperative, 3-dimensional registration of C-arm fluoroscopic images with spatially-registered ultrasound visualization and implant guidance of radioactive implants and on-line implant assessment during the procedure for treatment of prostate cancer. With present techniques using transrectal ultrasound guidan ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. Design & Synthesis of Novel Agents to Treat Amyloidosis

    SBC: Advanced Life Sciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The major goal of our proposed project is to advance the development of novel compounds for the treatment of amyloidosis and other protein aggregation diseases. Preliminary work demonstrated that two chalcones inhibited amyloid fibril formation, in vitro, and that further work is warranted. The amyloid diseases that arise from nonimmunoglobulin proteins includ ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  4. Selective Inhibitors of Pancreatic Cholesterol Esterase

    SBC: ALBUQUERQUE AVIAN EXOTIC            Topic: N/A

    DESCRIPTION (Scanned from the Applicant's Abstract): The specific aim of this esterase (CE) inhibitor in an acute cholesterol absorption assay. Hamsters will be gavage fed 3H-labeled cholesterol with CE-inhibitor ranging from 20-200 umoles. Twenty-four hours later, hepatic and serum cholesterol absorption will be assayed. Hepatic and serum cholesterol levels will be det ...

    SBIR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  5. Potential Brain Therapeutics

    SBC: AMERICAN BIOTECHNOLOGY RESEARCH CORP            Topic: N/A

    DESCRIPTION (provided by applicant): Use of botanical products such as exogenous antioxidants has gained considerable momentum in the last few years in therapy of human degenerative diseases. Among these antioxidants, tumeric, neem, guggul, alpha-tocopherol, Beta-carotene, and ascorbic acid have been shown to have a special relevance in maintaining the redox e ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  6. EXPANDING EXPERT WOUND CARE THROUGH TELEMEDICINE

    SBC: APPLIED HOME TELEMEDICINE, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Until recently, home health care agencies had absorbed an increasing demand for caring for older Americans. While demographic characteristics remain unchanged for our aging society, since 1997 thousands of home health agencies have closed. With the advent of prospective payment, thousands more are at risk of closure. Unless alter ...

    SBIR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  7. Emerging Weapons Technology Evaluation Model

    SBC: APPLIED SCIENCES LABORATORY, INC.            Topic: N/A

    Accelerated development of directed energy technologies has presented new problems to mission planners and weapon operators regarding the capabilities, lethality and performance of weapon systems. The Emerging Weapons Technology Evaluation Model willaddress these shortcomings by providing users of varying technical expertise 1) the ability to model a variety of weapons in various mission scenario ...

    SBIR Phase I 2003 Department of DefenseSpecial Operations Command
  8. Optical Trapping

    SBC: Arryx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the incident light) it's ability to manipulate biological particles such as macromolecules, viruses, microtubul ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  9. Molecular Manipulation with a Holographic Laser Tweezers

    SBC: Arryx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the incident light) it's ability to manipulate biological particles such as macromolecules, viruses, microtuble ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  10. Cartilage Repair by Engineered Implant Feasibility study

    SBC: ARTICULAR ENGINEERING, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This small business Innovation Research Phase I project proposes to define methodology to facilitate the growth of engineered cartilage tissue. Recent studies have demonstrated that the alginate recovered chondrocyte (ARC) method can be used to stimulate isolated adult articular chondrocytes in vitro to form viable cartilaginous tissue with good physiochemical ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
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