Award Data

An analysis of alternatives, including modeling, will be conducted of such candidates technologies such as localization, energy provision, and reporting, which are required for long-duration, LPD localization of various types of vessels operating in blue, green and brown water, with near-real time communications, to support global maritime tag track and locate capabilities in support of national a ...

Vadum proposes a feasibility study to define the next generation power amplifier for the Special Operations Forces (SOF) warfighter. This program will deliver extended bandwidth, more complex waveform capability, longer battery life, higher field reliability, and wide compatibility across radio types. The Phase I deliverable will be a comprehensive trade study and a proposed PA design which incl ...

Technical abstract 13.1-005 Today there is no sub-sonic ammunition currently type classified for use in the calibers provided by any DoD Service. Although sub-sonic rounds exist for some calibers, these rounds are not cost effective and exhibit excessive deviations in velocity (affecting accuracy), incomplete chamber sealing, absence of clean propellant burn, and inability to cycle the action on ...

To meet the critical security needs of the Department of Homeland Security and others, we propose two methods for providing a secure root of trust for mobile devices. One method is designed to integrate as easily into existing systems, while the other requires deeper integration but provides correspondingly stronger security. The keys to our work are practicality and integration: practicality to e ...

While most media attention in the wake of a terrorist attack, a natural disaster, or even a single building fire focuses rightly on the safety and wellbeing of the general public, one often overlooked aspect of these catastrophic events is the extreme risk taken by first responders who enter structures on the verge of collapse. For example, after the attacks on the World Trade Center on September ...

DESCRIPTION (provided by applicant): Standard microfracture is a first-line, widely used and cost-effective surgical technique for repairing damaged articular cartilage, but, it is limited by decreased long-term efficacy and limited applicability in largerlesions. This leads to a burgeoning economic burden associated with primary and follow-up treatment costs, estimated at more than 40 billion dol ...

DESCRIPTION (provided by applicant): Controlling mechanical signal transduction to treat osteoarthritis Abstract The TRPV4 calcium (Ca++) permeable ion channel has been shown to be expressed and functional in chondrocytes, the cells responsible for the maintenance of cartilage in weight-bearing joints. Trauma of joints with subsequent damage of cartilage, as well as chronically increased joint loa ...

DESCRIPTION (provided by applicant): Patients with infective endocarditis (IE) have a poor prognosis with one third of the patients succumbing to the infection within the first year. Treatments for endocarditis involve antibiotic therapy and/or surgery that cost upwards of 100,000 per patient; however, many cases do not respond to the antibiotic treatment and surgery poses high risks. Cases of en ...

DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. Innovative synthetic biology methods will overcome ...

DESCRIPTION (provided by applicant): Each year in the United States over 270,000 women will be diagnosed with breast cancer and over 40,000 will die from the disease. While multiple forms of breast cancer exist, a common theme in most of the forms involvesaberrations in signal transduction pathways that lead to inhibition of the programmed cell death process known as apoptosis. Apoptosis is a care ...