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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. COMPUTERIZED NONINVASIVE MONITORING OF BRAIN OXYGENATION

    SBC: ADVANCED BIOENGINEERING TECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by applicant): Stroke continues to be the number three principal cause of death, and one of the leading causes of disability, in the United States. Continued improvements in these statistics requires a better understanding of the functional dynamics of the cerebral vasculature and oxygen utilization of the surrounding tissue during various physiological conditions.We propose ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  2. MULTIRESOLUTION AUTOFOCUSING FOR AUTOMATED CYTOGENETICS

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    The goal of this project is to develop innovative digital microscope autofocusing techniques for automated cytogenetics applications. We propose a novel multi-resolution image analysis approach to focus measurement and detection, based on the recently developed mathematical theory of wavelet transform. In comparison to currently available single-resolution techniques, the proposed method overcom ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  3. IMPROVED IMAGING FOR PRECISE CRYTPIC ANOMALY DETECTION

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This project will further develop automated instrumentation and image analysis techniques to detect cryptic chromosomal rearrangements, which are difficult to detect by conventional cytogenetics. It combines two innovative FISH probes: "SubTelomeric" (STFISH) and "Multiplex" (MFISH), with sophisticated image analysis, ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  4. IMPROVED IMAGING FOR PRECISE CRYTPIC ANOMALY DETECTION

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This project will further develop automated instrumentation and image analysis techniques to detect cryptic chromosomal rearrangements, which are difficult to detect by conventional cytogenetics. It combines two innovative FISH probes: "SubTelomeric" (STFISH) and "Multiplex" (MFISH), with sophisticated image analysis, ...

    SBIR Phase II 2002 Department of Health and Human ServicesNational Institutes of Health
  5. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS

    SBC: AGENTASE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Agentase, LLC seeks follow-on Phase II Small Business Innovation Research funding to develop prototype formulations of chemically modified enzymes for the treatment and, more importantly, the prevention of organophosphorus poisonings. Several known enzymes exhibit hydrolytic activity on target organophosphorus compounds including nerve agent chemical weapons su ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  6. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS

    SBC: AGENTASE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Agentase, LLC seeks follow-on Phase II Small Business Innovation Research funding to develop prototype formulations of chemically modified enzymes for the treatment and, more importantly, the prevention of organophosphorus poisonings. Several known enzymes exhibit hydrolytic activity on target organophosphorus compounds including nerve agent chemical weapons su ...

    SBIR Phase II 2002 Department of Health and Human ServicesNational Institutes of Health
  7. QUANTITATIVE ANALYSIS OF RH ANTIBODIES

    SBC: Allied Innovative Systems LLC            Topic: N/A

    The objective of this proposal is to develop a quantitative ELISA assay for quantitative measurement of anti-RhD antibodies. Specific aims include isolation of soluble serologically active RhD, coating ELISA plates with the extract, enhancing the sensitivity of antibody detection using the Photochemical Amplification Method (PAM) and the Fluorescence Enhancement Technique (FET), measuring stabilit ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  8. NOVEL BIOIMAGING ANALYTICAL METHODS

    SBC: Allied Innovative Systems LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this proposal is to demonstrate the feasibility of a new approach to improving the performance of bio-molecular imaging methods. A new technology allows one to increase the signal-to-noise ratio, save costly reagents and reduce time of analysis of analytical bio-imaging techniques. This unique approach has never been used before for improvemen ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  9. CO-AMPLIFIED RNAS FOR COMPARITIVE MICROARRAY ANALYSIS

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    Ambion, Inc. proposes to develop methods and reagents that will make it possible to compare the expression profiles of small RNA samples (

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  10. SIRNA DESIGN, PRODUCTION AND DELIVERY

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): RNA interference is a new and powerful research tool that can be used to down regulate or knock out a specific gene or genes in a variety of cell types and organisms. Currently this technology is being used to study gene function, but may one day be used for human therapeutics. The RNAi phenomenon was only recently demonstrated to be present in mammalian cells ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
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