Award Data

DESCRIPTION (provided by applicant): ACell is a tissue engineering company and its core technology is based upon a porcine derived extracellular matrix (ECM) harvested from the urinary bladder (UBM) that serves as a constructive scaffold for tissue reconstruction. Successful completion of Phase I studies showed that the UBM-ECM can be configured into a tube shaped device with mechanical and materi ...

DESCRIPTION (provided by applicant): ACell is a tissue engineering company and its core technology is based upon a porcine derived extracellular matrix (ECM) harvested from the urinary bladder (UBM) that serves as a constructive scaffold for tissue reconstruction. Successful completion of Phase I studies showed that the UBM-ECM can be configured into a tube shaped device with mechanical and materi ...

DESCRIPTION (provided by applicant): Sudden cardiac death kills 300,000 people in the United States yearly. More than half of these deaths are caused by arrhythmias including ventricular tachycardia. Radiofrequency ablation, which successfully treats supraventricular tachycardia, is not successful at treating ventricular tachycardia because conventional RF ablation catheters cannot treat a large e ...

DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. While weight loss is the most effective treatment of type 2 diabetes, current methods for reducing weight are typically insufficient for long-term weight loss. The mission of AdipoGenix, Inc. is to discover, develop, and license novel therap ...

The goal of this project is to develop innovative digital microscope autofocusing techniques for automated cytogenetics applications. We propose a novel multi-resolution image analysis approach to focus measurement and detection, based on the recently developed mathematical theory of wavelet transform. In comparison to currently available single-resolution techniques, the proposed method overcom ...

DESCRIPTION (provided by applicant): This project will further develop automated instrumentation and image analysis techniques to detect cryptic chromosomal rearrangements, which are difficult to detect by conventional cytogenetics. It combines two innovative FISH probes: "SubTelomeric" (STFISH) and "Multiplex" (MFISH), with sophisticated image analysis, ...

DESCRIPTION (provided by applicant): This project will further develop automated instrumentation and image analysis techniques to detect cryptic chromosomal rearrangements, which are difficult to detect by conventional cytogenetics. It combines two innovative FISH probes: "SubTelomeric" (STFISH) and "Multiplex" (MFISH), with sophisticated image analysis, ...

It is becoming more difficult to treat bacterial infections such as, tuberculosis, staphylococcus, and streptococcus due to the emergence of multiple antibiotic-resistant strains. Rational drug design may prove invaluable for developing new antibiotic agents. Advanced Microbial Solutions Corporation (AMS) developing a new class of anti-microbial agents targeted at metal ion-activated transcription ...

DESCRIPTION (provided by applicant):Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes and molecular targets in small laboratory animals. Its fundamental advantage is that functional data can be obtained non-invasively, allowing each animal to be studied repeatedly. Thus, each animal can serve ...

DESCRIPTION (provided by applicant):Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes and molecular targets in small laboratory animals. Its fundamental advantage is that functional data can be obtained non-invasively, allowing each animal to be studied repeatedly. Thus, each animal can serve ...