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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Enhancing the immunogenicity of idiotypes for therapy of Non-Hodgkin's lymphoma

    SBC: ADVAXIS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Non-Hodgkin's Lymphoma (NHL) is characterized by an indolent clinical course with a median survival of 6- 10 years. The incidence of NHL in the US increases by about 2.5% per year. Clearly, there is a national need for improved therapies for this malignancy. Idiotype-based clinical trials for minimal residual disease of follicular NHL have shown increased disea ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. Transgenic Plant Technology for Producing Therapeutic Recombinant Antibodies

    SBC: Altor BioScience, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There is an urgent need to develop novel, cost-effective manufacturing processes to produce therapeutic antibodies commercially in order to reduce the high manufacturing expenses as well as to address the potential for limited manufacturing capacity. The long-term objectives of this application are to develop novel manufacturing processes using transgenic plant ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Tissue Factor Antagonists for ALI/ARDS

    SBC: Altor BioScience, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to develop an anti-tissue factor antibody, Sunol-cH36, as a treatment for Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The association between coagulation and inflammation has been well established and a central role in the coagulopathy of ALI/ARDS has been attributed to tissue factor (TF). TF binding ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  4. LOW-COST AFFINITY SYSTEM FOR PREPARATION OF PLASMA/SERUM FOR BIOMARKER ANALYSIS

    SBC: APD LIFE SCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We will develop a disposable, affinity-based capillary tube [AffiTip] that is capable of removing 99% of the interfering bulk protein from < 5 :L of undiluted plasma within 2 minutes for use prior to analysis for biomarkers [specific compounds that link mechanism of action and clinical effectiveness]. The product ultimately will be introduced at a sale price [p ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. Sphingosine Kinase Inhibitors as Anti-IBD Agents

    SBC: Apogee Biotechnology Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the development of new drugs for the treatment of Inflammatory Bowel Diseases (IBDs). Sphingolipids are being incre ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Anti-Atherosclerosis Agents Targeting Sphingosine Kinase

    SBC: Apogee Biotechnology Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Principal Investigator/Program Director: French, Kevin J. Abstract: The long-term goal of this program is to develop inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the development of new drugs for the treatm ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Microarrays in Fathead Minnows and Bass

    SBC: EcoArray, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Microarrays are a powerful way to measure the biological impact of contaminants in the environment. Because they are used to test changes in expression of many genes in parallel, they provide data on the mechanisms by which compounds affect health more quickly than methods now in use, which makes them much less expensive than current tests. Today, gene chips (m ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  8. SIMULATIONS FOR DRUG RELATED SCIENCE EDUCATION

    SBC: ARCHIE MD INC.            Topic: N/A

    N/A

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Wearable Seizure Warning Device

    SBC: CHATTEN ASSOC., INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In spite of advances in medical and surgical treatment, there are at any one time estimated to be some 350,000 individuals in this country whose seizures occur without warning and result in some combination of disordered thinking, impaired consciousness, or loss of motor control. Epileptologists and patients alike have long understood the magnitude of this prob ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. Bathing aids palliative cancer care &amp; aging-in-place

    SBC: AUGMENTECH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose developing bathing assistance technologies that are closely related at the device level for two very distinct, but important and underserved populations of potential users: 1) bedroom bathing for people with fragile skin receiving palliative care for advanced cancers and 2) ground floor bathing for elderly mobility impaired people who cannot afford t ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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