The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.
Protein Qspec: An Improved Method for Rapid Characterization of Protein Aggregates in Biologic Drugs for Increased Quality and SafetySBC: OPTOFLUIDICS, INC. Topic: 90201
Optofluidics will develop Protein Qspec, a new particle analysis QC instrument designed to characterize protein aggregates in biologic drugs. The primary concern for this class of therapeutics is that they can elicit an immune response from patients who develop anti-drug antibodies which can eliminate the therapeutic benefit. The presence of particulate matter, in these therapeutics (e.g. shed gla ...SBIR Phase I 2016 Department of CommerceNational Institute of Standards and Technology
SBC: O'donnell Consulting Engineers Topic: N/A
STRESSES DUE TO PRESSURE AND REPEATED THERMAL CYCLING CAUSE PROGRESSIVE MATERIAL DAMAGE DURING THE OPERATION OF LWR COMPONENTS AND PIPING SYSTEMS. THE PRESENT PRO POSED RESEARCH WOULD IMPROVE THE ACCURACY OF EXISTING S- N FATIGUE EVALUATION METHODS BY COMBINING THEM WITH THE ADVANCED TECHNOLOGY OF CRACK PROPAGATION AND FRACTURE MECH ANICS. ENVIRONMENTAL EFFECTS WILL BE INCLUDED IN THE CRACK PROPAG ...SBIR Phase II 1986 Nuclear Regulatory Commission
SBC: Pentek Inc. Topic: N/A
PENTEK WILL DEVELOP AND TEST A TECHNIQUE TO DETERMINE THE FUNCTIONALITY OF SOLENOID-OPERATED VALVES IN A NUCLEAR POWERPLANT BASED ON THE MEASUREMTNT AND ANALYSIS OF IN-RUSH CURRENT. THE TECHNIQUE WILL BE DEVELOPED SO THAT ALL MEASUREMENTS CAN BE MADE FROM OUTSIDE THE REACTOR BUILDING WITHOUT DISTRUBING ANY ELECTRICAL CONNECTIONS. THE ANALYSIS METHODS WILL BE DEVELOPED FOR ON-LINE USE WITH A PERSON ...SBIR Phase I 1986 Nuclear Regulatory Commission