Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Development of a blood test for breast cancer detection

    SBC: INTEGRATED TECHNOLOGIES AND SRVCS INTRNTL            Topic: N/A

    DESCRIPTION (provided by applicant): Mammography is the benchmark for breast disease detection and diagnosis. However, it can miss 10-15% of early stage breast cancers, and it is unable to distinguish between benign and malignant lesions with certainty. Av ailability of an alternate method e.g. biomarker based, which allows early detection/precise distinction between benign disease and breast canc ...

    SBIR Phase I 2008 Department of Health and Human Services
  2. Sphingosine Kinase Inhibitors as Anti-Arthritis Agents

    SBC: Apogee Biotechnology Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Sphingolipids are being increasingly recognized as key mediators of inflammatory cascades of critical importance in multiple diseases, including rheumatoid arthritis and osteoarthritis. Most importantly, sphingosine 1-phosphate produced by sphingosine kinase (SK) mediates the effects of tumor necrosis factor-1 and interleukin-12, pro-inflammatory cytokines ...

    SBIR Phase II 2008 Department of Health and Human Services
  3. ALEXSA Adaptation for Use in Large Scale Substance Use Surveys

    SBC: ASSESSMENTS ILLUSTRATED            Topic: N/A

    DESCRIPTION (provided by applicant): This NIDA STTR reapplication is to develop a personal digital assistant (PDA) format of a validated child self- report (Assessment of Liability and EXposure to Substance use and Antisocial behavior(c) or ALEXSA(c)) for early harmful substance use, antisocial behavior, and risks for these behaviors. Large markets for this instrument include large-scale surveil ...

    STTR Phase I 2008 Department of Health and Human Services
  4. A novel approach for gene therapy

    SBC: ATIGEN            Topic: N/A

    DESCRIPTION (provided by applicant): Many human diseases have been traced back to single genetic mutations in the genome that are causative for the disorder, such as Lesch-Nyhan Syndrome, Cystic Fibrosis, Tay-Sachs disease and Duchenne muscular dystrophy. The goal of this proposal is to proof the feasibility of a newly developed technology for gene- therapy that targets RNA transcripts of mutated ...

    STTR Phase I 2008 Department of Health and Human Services
  5. Development of Radiopharmaceuticals for Imaging Brain Tau Pathology

    SBC: AVID RADIOPHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is the most common cause of dementia in the elderly, with more than 4.5 million Americans currently suffering from the disease. Clinical management of AD is complicated by lack of effective meth ods for early and accurate diagnosis of the disease. Thus, there is a significant unmet need for Alzheimer's disease diagnostic tools. The hypo ...

    SBIR Phase I 2008 Department of Health and Human Services
  6. 18F-AV-133, A Novel Radiopharmaceutical for Differential Diagnosis of Dementia

    SBC: AVID RADIOPHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Dementia, with its most prevalent subforms Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia, is a very substantial medical and societal problem. The emergence of many drugs and drug can didates that interfere with the disease mechanism of specific types of dementia makes it crucial to distinguish early between the various forms ...

    SBIR Phase I 2008 Department of Health and Human Services
  7. 18F-AV-45 PET Imaging of Amyloid in PD with Cognitive Impairment

    SBC: AVID RADIOPHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Dementia associated with PD (PDD) is common (affecting up to 80% of patients long-term) and highly disabling. Informative biomarkers are urgently needed to understand the pathology of PDD, to improve the early detection of cognitive deficits and to facilitate the development of treatments for PDD. Nuclear imaging technologies have the potential to produce such ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. Tendrils: A Multimedia Intervention for Women's Sexual Dysfunction after Cancer

    SBC: Digital Science Technologies LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Long-term Objectives Aims: Sexual dysfunction is the most common long-term consequence of cancer treatment, affecting half of survivors of breast and gynecological cancer and many women treated for other cancers. Yet, f ew women get the help they need for sexual problems. Our primary objective is to develop and evaluate a multimedia intervention program for wom ...

    STTR Phase II 2008 Department of Health and Human Services
  9. Nanochannel Devices for High Throughput Single Molecule DNA mapping and Haplotypi

    SBC: BIONANOMATRIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long term objective of this proposal is to develop a fully integrated nanochannel chip and reader capable of single molecule mapping of linearized, long genomic material. The anticipated embodiment will permit dire ct visualization and analysis of megabase fragments of DNA extracted directly from a sample (possibly a single cell) with sub-kilobase resoluti ...

    SBIR Phase I 2008 Department of Health and Human Services
  10. Magnetic Navigated Image Overlay for Vascular Access- MNIO-VA

    SBC: BLUE BELT TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to combine magnetic sensor (MN) navigation technology developed for prenatal cardiac intervention (R44HL076961) with our image overlay (IO) solutions to produce an accurate and user- accessible system for rapid, central vascular access (MNIO-VA). Central vascular access is the critical first step in many medical procedures (intravenous infus ...

    STTR Phase I 2008 Department of Health and Human Services
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