Award Data

DESCRIPTIONprovided by applicantThe Cell SafeTM is a fundamentally new approach in replacement of dysfunctional insulin producing cells in patients with diabetesby transplantation of new islets in a three dimensional scaffold embedded in a highly compatible bioengineered perfusion system that continuously supplies tissue fluidblood ultrafiltrateso that the cells ae protected from immune rejection ...

PROJECT SUMMARY Novel inhibitors of Zika virusZIKVare urgently needed to prevent the occurrence of virus induced microcephaly and Guillain BarrsyndromeThe objective of this Phase I SBIR feasibility study is to identify drug like compounds that specifically inhibit ZIKV replicationDuring the course of this Phase I funding periodwe will execute hit finding campaign against a library ofcompounds with ...

The goal of this Phase I clinical trial will be to document safety and potential usefulness ofdemethylcholesteryloxycarbonylpenclomedineDM CHOC PENin combination with de escalating doses of whole brain radiation therapyWBRTas binary therapy in subjects with advanced cancer involving the CNSa Phase I clinical trialDM CHOC PEN is a polychlorinated pyridyl cholesteryloxycarbonatewhich has completed P ...

IND enabling Studies of ZB an Orally Bioavailable SERD Project Summary Most patients with advanced metastatic breast cancer eventually develop resistance to tamoxifen or aromatase inhibitor AI treatment where the recurrent and or progressive disease retains the expression of ER The standard treatment of breast cancer progressing after tamoxifen or AI therapy is fulvestrant which is the onl ...

Abstract Five Eleven Pharma is developing a simple low cost device for automating the preparation of Ga labeled drugs at any site that is performing PET imaging The device is being developed to support the broader creation distribution research and use of Ga compounds in diagnostic PET imaging There has been a surge in the use of Ga based radiopharmaceuticals throughout the world in ...

ABSTRACT The estimates of natural product producing gene clusters within the genomes of microorganisms are far greater than the number of known natural products indicating that there is a wealth of untapped molecules within these organisms that offer huge potential as leads for new medicines Unfortunately the prevailing paradigms for natural product discovery are ill suited for accessing this ...

Project Summary Extended X ray absorption fine structure EXAFS is a technique that gives element specific structural and chemical information about molecules EXAFS currently requires bright X ray beams from specialized synchrotron light sources for most samples and so its applications are limited by access to these facilities This project will involve improved X ray detectors based on superco ...

Project Summary Abstract Phenylketonuria PKU is a serious inborn metabolic disorder affecting out of every children born in the U S annually Characteristic effect of PKU is the impaired capability of the body to convert the amino acid phenylalanine Phe to tyrosine and as a result Phe level is elevated in the blood stream While Phe is required for normal growth and brain developm ...

DESCRIPTION provided by applicant The most common hemodialysis catheter complications are thrombosis inflammation and biofilms Thrombotic deposition and inflammation have been shown to result in inadequate dialysis and lead to higher complication rates and increased mortality and can take many different forms including isolated clots thrombosis in vessels adjacent to the catheter tip or f ...

PROJECT SUMMARY Over the last two decades the commercialization of silicone hydrogel andquot SiHyandquot composite technologies has led to new soft CLs that are more breathable comfortable and affordable including in daily disposable versions which have considerably broadened the customer base especially among younger generations Despite these improvements the major persistent problem fa ...