Award Data

DESCRIPTION provided by applicant Scarab Genomics was founded to improve E coli as an industrial organism by genome engineering These strains have stable genomes since all prophages transposable and IS elements and the error prone repair systems were removed A recA version has always been provided as an option The goal of the Phase I project was to ascertain whether the changes already in ...

DESCRIPTION (provided by applicant): Our goal in this Phase 2 SBIR proposal is to develop and optimize the components for a novel cell migration assay. In Phase 1, we demonstrated that liquid crystals assume a predictable orientation in response to cellular membranes, and therefore they could be used in a sensitive, rapid, generalizable method for reporting cell number. In this application, we pro ...

Intraband, LLC has invented and demonstrated quantum-cascade-laser (QCL) structures that both suppress carrier leakage and have efficient carrier extraction, so-called step-taper active-region (STA) QCLs. As a result, record-high internal efficiencies have been obtained, which are 30-40 % higher than conventional QCLs. Consequently, these midwave infrared (MWIR) semiconductor lasers have potential ...

Swallowing disorders known as dysphagia are associated with increased mortality and morbidity including malnutrition dehydration pulmonary complications and reduced quality of life More than M adults and millions more children suffer from dysphagia This disorder commonly causes liquids whether overly thin water coffee or overly thickened to be aspirated or misdirected into the air ...

DESCRIPTION (provided by applicant): Severe burns and other major trauma to the skin are life-threatening injuries that often require immediate surgical intervention. Typically, this involves temporary coverage of the wound site with cadaver skin or synthetic dressings to prevent infection and dehydration. Permanent closure of the wound is generally accomplished through split-thickness skin autogr ...

Numerous clinical studies have described the negative impact of radiotherapy-induced dermatitis on cancer patients during and after their 5-6 week course of radiotherapy. Virtually all patients develop at least a mild dermatitis, and for almost half it's a painful side effect lasting weeks. There can be scarring, limitations on more aggressive radiotherapy, and can result in patients quitting radi ...

DESCRIPTION (provided by applicant): Our goal is to improve the versatility, safety and effectiveness of E. coli as a platform for commercial production of DNA, proteins and metabolites. The natural E. coli genome will be reduced to its essentials by removing unnecessary, detrimental and potentially harmful genes through our Scarless Genome Reduction (SGR) technology. The result will be a robus ...

Abstract In humans and animals G protein coupled receptors GPCRs are embedded on cell surfaces and function as key regulators of physiological events by transmitting signals from extracellular stimulants across the cell membrane into the cell Impaired or abnormal GPCR function can result in disordered physiological processes causing a broad and diverse range of diseases For this reason GPCRs ...

DESCRIPTION (provided by applicant): Reading the conformational state of membrane proteins is central to understanding their role ir cell signaling, to using them as sensor elements and for screening candidate drug compounds that are targeted toward this important class of biomolecules. While the patch clamp technique for doing this is ubiquitous, it does have significant limitations: two electrod ...

DESCRIPTION (provided by applicant): Reading the conformational state of membrane proteins is central to understanding their role ir cell signaling, to using them as sensor elements and for screening candidate drug compounds that are targeted toward this important class of biomolecules. While the patch clamp technique for doing this is ubiquitous, it does have significant limitations: two electrod ...