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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microfluidic DNA Sequencing

    SBC: GNUBIO, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a microfluidic platform and camera system, and analysis methodology that enable genome alignment and variant ca ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Chlorolog: Production Scaling and Testing of a Fast-Acting, Ultra-stable Insulin

    SBC: THERMALIN DIABETES, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): We seek to develop a novel insulin analog to enhance the safety and efficacy of insulin pump therapy with broad application to the Artificial Pancreas Project ( smart pumps ). A proprietary approach is proposed basedon the favorable physico-chemical properties conferred by chloro-aromatic substitutions in the insulin molecule. This Phase 2 SBIR application th ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. RandD- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

    SBC: IMMUNETICS, INC.            Topic: NHLBI

    This project is aimed at the development of an enzyme immunoassay (ELISA) for screening blood for antibodies to Babesia microti. Human babesiosis is a malaria-like illness due to infection of red blood cells by various species of protozoan parasites belonging to the genus Babesia. Most human infections reported in the United States are caused by B. microti which is endemic in parts of the northeas ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. ChNKG2D-Targeted Cellular Cancer Therapy: Phase I Clinical Trial

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The global burden of cancer doubled between 1975 and 2000. Cancer became the leading cause of death worldwide in 2010, and is projected to double again by 2020 and to triple by 2030. This horrible disease has touched each of us, and despite enormous investments in prevention and treatment, its impact continues to accelerate. Ideally, any cancer therapy should ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Pre-clinical Development of a Context-Dependent NMADR Neuroprotectant for Treatme

    SBC: NEUROP, INC.            Topic: 102

    DESCRIPTION provided by applicant Cerebral ischemia is a major cause of death and long term disability with high accompanying social and medical costs Approximately Americans suffer a stroke each year at an estimated annual cost of $ B American Heart Association Heart Disease and Stroke Statistics Update Substantial preclinical data support the use of NMDA receptor antago ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  6. Development of an Anti-P-selectin Antibody for the Treatment of Sickle Cell Disea

    SBC: SELEXYS PHARMACEUTICALS CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Selexys Pharmaceuticals is developing a humanized monoclonal antibody drug called SelG1 directed against P-selectin for the treatment of vasoocclusive crisis in patients with sickle cell disease. The ultimate goal of this Phase IIB proposal is to further advance SelG1 into Phase II/III safety and efficacy trials to support of regulatory filings for FDA approval ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. IMPROVING MANUFACTURING AND POTENCY OF CRYOPRESERVED MALARIA SPOROZOITE VACCINE

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The development of Sanaria's aseptic, purified, cryopreserved Plasmodium falciparum (Pf) sporozoite (SPZ)-based products has received international recognition during the past year, due principally to four findings: 1)PfSPZ Challenge (infectious PfSPZ) induced malaria in volunteers, 2) PfSPZ Vaccine (radiation attenuated PfSPZ) induced unprecedented levels ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. A fully integrated assay and platform for detecting Clostridium difficile.

    SBC: Claremont BioSolutions            Topic: NIAID

    DESCRIPTION (provided by applicant): The primary goal of this proposed project is to develop a point-of-care diagnostic assay and platform for the detection of Clostridium difficile from human stool. Two additional goals are to detect the hypervirulent strain of C. difficile B1/NAP/027 and to detect C. difficile spores from swabs of medical devices. C. difficile associated disease (CDAD) is now th ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Development of RLIP76 protein as a Radiation Countermeasure

    SBC: TERAPIO            Topic: NIAID

    DESCRIPTION (provided by applicant): There remains a critical need for medicines that can counteract the toxic effects of radiation exposure. Terapio is developing a recombinant protein, RLIP76, for use as a radioprotectant for workers, military personnel, or civilians that are either in imminent danger of radiation exposure, or have already been exposed. In research carried out at the Unive ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. A Rapid Point-of-care Diagnostic for C. trachomatis STDs

    SBC: NetBio, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Improved diagnosis of Chlamydia trachomatis (Ct) infections represents a critical unmet medical need. Ct is the most common cause of bacterial sexually transmitted diseases (STD) worldwide, and the Centers for Disease Control and Prevention estimate that there are 2.8 million US cases annually. Currently, 40% of women with untreated infection will develop pelvi ...

    SBIR Phase II 2012 Department of Health and Human Services

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