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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. The Remote Brief Intervention and Referral to Treatment service for Alcohol (R-BI

    SBC: POLARIS HEALTH DIRECTIONS, INC            Topic: NIAAA

    DESCRIPTION (provided by applicant): Although the USPHSTF, SAMHSA, the CDC, and NIAAA have affirmed the central role that healthcare providers play in screening, brief intervention, and referral to treatment (SBIRT) for alcohol abuse, translation of theserecommendations to clinical practice continues to be elusive. To address this problem, Polaris Health Directions (Small Business) and the Univers ...

    STTR Phase I 2012 Department of Health and Human Services
  2. Human Lactoferrin in Acetaminophen Overdose-Induced Liver Failure

    SBC: VENTRIA BIOSCIENCE            Topic: NIAAA

    DESCRIPTION (provided by applicant): An acute or cumulative overdose of acetaminophen (APAP), following either therapeutic overdose or suicide attempts, can cause severe liver damage with the potential to progress to liver failure. APAP overdose accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year, making APAP ...

    STTR Phase I 2012 Department of Health and Human Services
  3. CSF Tau Biomarker-guided Development of Hsp90 Inhibitors for Alzheimer's Disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION (provided by applicant): Research and Related Other Project Information Item 7. Project Summary/Abstract Neurodegeneration in Alzheimer's disease (AD) may result from deposition of A as plaques in brain tissue. However, less effort has been made to elucidate the role of tau- containing neurofibrillary tangles (NFTs) in AD. Accumulating evidence suggests that tau containing NFTs i ...

    STTR Phase I 2012 Department of Health and Human Services
  4. Drug regulators of nitric oxide production as Alzheimer's disease therapeutics

    SBC: Epigen Biosciences, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): Druggable regulators of nitric oxide production as new Alzheimer's disease therapeutics Summary: Nitrosative stress is a critical mediator of the onset and progression of Alzheimer's disease (AD): it precedes and is associated with neuritic dystrophy and dendritic spine loss, A /amyloid accumulation and deposition, cholinergic denervation and a memory ...

    STTR Phase I 2012 Department of Health and Human Services
  5. Preclinical Development of a New Drug for Treating Anemia of Chronic Inflammation

    SBC: CUMBERLAND PHARMACEUTICALS INC.            Topic: NIA

    DESCRIPTION (provided by applicant): A strong unmet need exists to develop new treatments for anemias associated with chronic disease states, collectively referred to as anemia of chronic inflammation (ACI). ACI is highly prevalent in the U.S. and makes alarge contribution to public morbidity and mortality. Despite billions of dollars spent annually to treat ACI patients, current therapies lack e ...

    STTR Phase I 2012 Department of Health and Human Services
  6. The Memory Care Navigator: A Proactive Guide

    SBC: Proactive Memory Services            Topic: NIA

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is an irreversible neurological disease that progressively causes a tremendous toll in disability and societal cost. As our population ages, AD and other memory disorders will become increasingly prevalent. Patients and their families often find themselves lost in a complex web of multiple providers, receiving conflicting recommend ...

    STTR Phase I 2012 Department of Health and Human Services
  7. Development of a Novel Therapeutic for Alzheimer' Disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Traditional approaches to drug development for Alzheimer's disease are becoming increasingly expensive and in many cases disappointingly unsuccessful. Based on preliminary in vitro and in vivo studies we have identifieda novel lactam derivative of the commonly prescribed 1,4 dihydropyridine calcium channel blocker nifedipine (1-acetyl-2,4- dimethylbenzo[c] ...

    STTR Phase I 2012 Department of Health and Human Services
  8. Speech-based biomarkers of CNS dysfunction associated with early Alzheimers disea

    SBC: KOBAK, KENNETH A            Topic: NIA

    DESCRIPTION (provided by applicant): More efficient methods to screen and monitor elderly patients in clinical practice and research are needed, but visits to clinical offices are expensive and many older patient are restricted by mobility or transportation access. The Alzheimer's Disease Cooperative Study (ADCS) is evaluating several technology platforms for remotely monitoring patient stat ...

    STTR Phase I 2012 Department of Health and Human Services
  9. Long-Term Broad-Spectrum Prevention of Implant-Related Infections

    SBC: Biomedical Development Corporation            Topic: NIA

    DESCRIPTION (provided by applicant): Deep wound infection following total joint arthroplasty is a devastating complication for physician and patient, a leading cause of morbidity, and a significant economic burden to the healthcare system. With an aging population and increased life expectancies, the number of arthroplasties is expected to rise dramatically over the next 20 years. The growing numb ...

    STTR Phase I 2012 Department of Health and Human Services
  10. Point-of-Care Diagnostic Test for Entamoeba histolytica Cysts

    SBC: TECHLAB, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The NIAID Category B priority pathogen Entamoeba histolytica is a public health threat, especially as a cause of diarrhea in travelers to and immigrants from endemic areas, men who have sex with men, and children in thedeveloping world where it is in the top 5 causes of severe diarrhea. It is also a biodefense threat to water and food supplies due to its resist ...

    STTR Phase I 2012 Department of Health and Human Services

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