Award Data

The technical objectives of this proposal are: 1) Implement the design developed in Phase I for the realization of 8 micron-emitting active-photonic-crystal (APC) quantum-cascade (QC) lasers of 3 W average, diffraction-limited power and 15 % wallplug efficiency in quasi-CW operation; 2) Design and realize 4.6 micron-emitting APC QC lasers of 3 W CW diffraction-limited power and 15 % wallplug effic ...

The Phase II program proposes to commercialize frequency quadrupling technology developed in the College of Optical Sciences at the University of Arizona to build a 244 nm UV frequency quadrupled optically pumped semiconductor laser (FQ-OPSL). The laser will provide a self-contained small footprint (

DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

DESCRIPTION (provided by applicant): Respiratory infections have a significant health and economic impact worldwide. Current test products for the diagnosis of respiratory viral infections such as influenza are inadequate for the timely diagnosis needed for successful implementation of antiviral treatment. Unfortunately a test product that can accurately diagnose common respiratory viruses with hi ...

DESCRIPTION (provided by applicant): 100,000 Americans perish each year due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant. The best possible source for new antibiotic structures with potentially novel mechanisms of action is within natural environments, particularly s ...

DESCRIPTION (provided by applicant): Current NIGMS-SBIR funding supported InvivoSciences LLC's (IVS) launch of several product lines in 2010. IVS generated revenues from the sales of three-dimensional (3D) cell culture tools (MC-8TM and IVS InsertsTM) thatcan grow various hydrogel tissues without any support layers. The culture tools enable Palpator TM and Tissue StretcherTM to stretch the hy ...

DESCRIPTION (provided by applicant): A major goal in the post-genomic era is to express the vast collection of protein- coding sequences, eventually resulting in a better understanding of protein interactions and the development of novel therapeutics. Themost favored host for heterologous recombinant protein expression is Escherichia coli. Despite many improvements, producing soluble proteins in E ...

DESCRIPTION (provided by applicant): Patient socket performance is a critical barrier to progress in rehabilitation, the most common source of patient dissatisfaction and part of a growing medical and socioeconomic problem. Poor socket performance is a greatly uncharacterized multi-factorial problem that leads to skin degeneration and patient discomfort (~75% of all patients). This proposal has a ...

DESCRIPTION (provided by applicant): Approaches to drug screening typically involve dramatic compromises in order to achieve high throughput and hold down costs. Examples include the use of immortalized, heterologous cell lines, and genetic engineering toover-express the target protein and/or incorporate a fluorescent surrogate reporter to display the result. At least partly because such systems o ...

DESCRIPTION (provided by applicant): Schizophrenia is a chronic and debilitating disorder that impacts nearly 1% of the world's population. The burden on the families and caregivers of patients is immense, with the cost of care in the United States being greater than 60 billion annually. The exorbitant financial strain of schizophrenia arises, in large part, to a lack of innovation that has ...