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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Ex Vivo Tolerance for Xenotransplantation of Diabetes P2

    SBC: XIMEREX, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have limited utility because of a severe shortage of donors and the need for constant immune suppression to prevent rejection. Pigs ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. RADIOGRAPHIC CONTRAST TO DIFFERENTIATE CAVITATED FROM NON-CAVITATED DENTAL CARIES

    SBC: FIREFLY HEALTH INNOVATIONS NE, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): This project relates directly to the PHS 2011-2, Omnibus Solicitation for SBIR/STTR Grant Application page NIDCR 110: Development of instrumentation for early caries detection and comparison studies on specificity andselectivity with respect to current clinical practice. The proposed test is intended to enable dentists to differentiate between cavitated and ...

    STTR Phase I 2012 Department of Health and Human Services
  4. Development of Ultrafine Particles for Intranasal Delivery of Antipsychotics

    SBC: LNKCHEMSOLUTIONS            Topic: NIMH

    DESCRIPTION: The goal of the proposed project is to develop a biocompatible ultrafine particle-based vector system for the intranasal delivery of clozapine for the pharmacological therapy of treatment- resistant schizophrenic disorders and their associatedsuicidal behavior. The rationale behind the use of intranasal clozapine is grounded on the observation of clozapine's extensive first- pass ...

    STTR Phase I 2012 Department of Health and Human Services
  5. Early Detection of Pancreatic Cancer Using Ice COLD-PCR

    SBC: TRANSGENOMIC, INC.            Topic: NCATS

    DESCRIPTION (provided by applicant): Ninety percent of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). PDAC diagnosis is difficult, usually occurring in the late stages of disease. Patients with these advanced tumors typically respondpoorly to therapy. Post diagnosis, median survival is 6 months and the five-year survival rate is lt 4%. Five-year survival is lt 1% for those wi ...

    STTR Phase I 2012 Department of Health and Human Services
  6. Piezoelectric Pipetting for High Density Nucleic Acid Programmable Protein Arrays

    SBC: ENGINEERING ARTS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Among the currently available techniques for high throughput proteomics, protein microarrays have the greatest prospects to revolutionize molecular diagnostics for early detection, diagnosis, treatment, prognosis and monitoring clinical response. However, protein microarrays have yet to reach their full potential as a research or clinical molecular diagnostics ...

    STTR Phase II 2012 Department of Health and Human Services
  7. Control Your Cravings: A Web-Based Transdiagnostic Self-Management Program

    SBC: GOALISTICS, LLC            Topic: NIDA

    DESCRIPTION (provided by applicant): Craving, when viewed as a compelling desire to consume a potentially harmful substance or to engage in a potentially harmful act, has been increasingly targeted for basic research, clinical assessment, and treatment. The management of cravings is a critical component of treatment for self- regulatory problems such as substance and alcohol abuse, overeating, gam ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. HAZworker- Web-Based, Multiplayer Small Group Simulation

    SBC: Inxsol LLC            Topic: NIEHS

    DESCRIPTION: Project Summary inXsol proposes to design and demonstrate a web-based, multiplayer small group simulation to support instructor led HazMat worker health and safety training. This product is called HAZworker. The use of distributed, low-cost simulation will allow individuals to attain a level of experience in the probable roles at typical incidents and work sits and to receive the nece ...

    SBIR Phase I 2012 Department of Health and Human Services
  9. VoxelDiscovery 5-8: Engaging the Middle Grades in Visualization of the Brain

    SBC: SCIENCE-APPROACH            Topic: NICHD

    DESCRIPTION (provided by applicant): VoxelDiscovery 5-8: Engaging the Middle Grades in Visualization of the Nervous System proposes to empower middle school students to use modern neuroimaging research to explore questions relevant to young adolescents lives and health, such as: (1) Are all people wired the same way?; (2) How is my brain changing as I grow up and why do I think the way I do?; (3) ...

    SBIR Phase I 2012 Department of Health and Human Services
  10. Method Development for a Next Generation Miniaturized Genomic Screening Platform

    SBC: ENGINEERING ARTS, LLC            Topic: NHGRI

    DESCRIPTION (provided by applicant): Every gene has its own set of small RNA molecules, known as small interfering RNA (siRNA), that inhibit expression of the gene's proteins. The siRNA molecules are part of an ancient natural mechanism of gene regulation,known as RNA interference (RNAi) that has been evolutionarily conserved since the earliest eukaryotic cells. More recently researchers have ...

    SBIR Phase I 2012 Department of Health and Human Services

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