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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ParkinStep: Automated PD Gait and Balance Assessment for Optimizing DBS

    SBC: Great Lakes Neurotechnologies Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess ParkinStep, an innovative neurotechnology that integrates wireless motion sensing, automated home-based Parkinson's disease (PD) gait and balance assessment, anddeep brain stimulation (DBS) parameter estimation using a web-based database model to integrate data across clinical centers. Following DBS ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Subcellular imaging of biochemical processes within human retina

    SBC: Polgenix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): Polgenix, Inc. is developing an imaging instrument, the 2-photon ophthalmoscope , or 2PO , with the capability for non-invasive, repetitive and high-resolution imaging of biochemical processes within human retina.This device will allow early detection of age- and disease- related changes in the eye, long before pathological manifestations of retinal disea ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Online Parent Training for Children with Behavior Disorders

    SBC: FAMILY WORKS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Research has shown that parent-targeted interventions are effective in ameliorating conduct disorders, substance abuse, HIV-risk, and related adolescent problem behaviors. During periods of economic turmoil, however, major obstacles such as affordability impede the effective delivery of support services. Ethnic minorities are especially disadvantaged with respe ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Chlorolog: Production Scaling and Testing of a Fast-Acting, Ultra-stable Insulin

    SBC: THERMALIN DIABETES, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): We seek to develop a novel insulin analog to enhance the safety and efficacy of insulin pump therapy with broad application to the Artificial Pancreas Project ( smart pumps ). A proprietary approach is proposed basedon the favorable physico-chemical properties conferred by chloro-aromatic substitutions in the insulin molecule. This Phase 2 SBIR application th ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Complement Inhibitors for Macular Degeneration

    SBC: Novelmed Therapeutics Inc            Topic: NEI

    DESCRIPTION (provided by applicant): According to the World Health Organization (WHO) global eye disease survey, 14 million people are blind or severely visually impaired due to age-related macular degeneration AMD. This disease affects the central visionof adults over the age 65. Degenerative changes of the Bruch's membrane and the retinal pigment epithelium in the macula (central retina) in ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. ElectroPolishing for Cost Effective, High Yield Nitinol Stent Fabrication

    SBC: Faraday Technology, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Faraday Technology proposes to develop the FARADAYIC [ElectroPolishing Process, based on pulse reverse electrolytic polishing of stents, fabricated from nitinol and other materials of interest to industry, for rapid, cost-effective surfce finishing] in a simple aqueous electrolyte. This process will minimize the process control difficulties and high reject rate ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Optimizing the Action Potential of Stem Cell-derived Human Cardiomyocytes for Car

    SBC: CHANTEST, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Stem Cell-derived Human Cardiomyocytes (SC-hCMs) offer great potential for improving the accuracy of pre- clinical cardiac safety testing. We have characterized a population of SC-hCMs and have demonstrated that these cells show sensitive pharmacology that accurately predicts clinical responses. However, due to low assay throughput and limited resources, only 1 ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. PDRemote: Automated Telehealth Diagnostics for Remote Parkinson's Monitoring

    SBC: Great Lakes Neurotechnologies Inc.            Topic: NIMHD

    DESCRIPTION (provided by applicant): The objective is to build and clinically assess PDRemote, a system for automated telehealth diagnostics for remote Parkinson's disease (PD) monitoring. Currently in the United States, there are approximately 1.5 millionpatients living wit PD and 50,000 new cases reported each year. However, there is limited access to movement disorder specialist centers fo ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. BradyXplore: Bradykinesia Feature Extraction System

    SBC: Great Lakes Neurotechnologies Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): The objective is to design, implement, and clinically assess a portable, user-worn, bradykinesia feature extraction system, BradyXplore , for integration with Great Lake Neurotechnologies' (GLN) Kinesia and Kinesia HomeView technology platforms for objective Parkinson's disease (PD) monitoring. There has been tremendous research into PD treatments in ...

    SBIR Phase II 2012 Department of Health and Human Services

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