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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Therapeutic Inhibition of MIF in Rheumatoid Arthritis

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): The long-term product goal of this project is a small molecule therapeutic to treat rheumatoid arthritis (RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). Since MIF is an upstream regulator of the inflammatory cascade, small molecule therapeutics targeting MIF activity ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Measurement of Beta Cell Death in Diabetes

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose islet or pancreas allografts. New therapies have been developed that can modulate the course of T1D but the effective appli ...

    STTR Phase I 2012 Department of Health and Human Services
  3. Computational Tools for Research in Neuroscience, Behavioral Science and Mental H

    SBC: Molecular Neuroimaging, L.l.c.            Topic: NINDS

    DESCRIPTION (provided by applicant): We propose to develop a software package to automatically evaluate a subject's beta amyloid PET scan (using either C11-PIB, F18-florbetaben, or F18-florbetapir, F18-flutemetamol) by normalizing the subject's scan, masking away non-gray matter tissue (without relying on co-registered MRI scans), placing standardized ROIs onto the transverse slices, and ...

    STTR Phase II 2012 Department of Health and Human Services
  4. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 38,000 confirmed and probable cases reported to the CDC in 2009. Spirochetes first establish infection in the skin and then disseminate to internal organs such as the heart, the joints, and the ...

    SBIR Phase I 2012 Department of Health and Human Services
  5. Hsp90 inhibitors to combat antifungal drug resistance.

    SBC: LIFEPHARMS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Fungal infections continue to be a major cause of morbidity and mortality among HIV-infected patients. Many of the emerging fungal pathogens that are resistant to the three classes of antifungal agents for AID-s-relatedinfections are becoming more common and are associated with higher rates of mortality. Combating drug resistant fungal pathogens should be a top ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Saliva Analyzer for Diagnosing SRD Patient Drug Use

    SBC: REAL-TIME ANALYZERS, INCORPORATED            Topic: NIDA

    DESCRIPTION (provided by applicant): The overall aim of this SBIR program is to develop a surface-enhanced Raman spectroscopy (SERS) based device for on-site analysis of drugs in saliva. This device will allow immediate assessment of both medicinal and illicit drug use by patients with substance-related disorders (SRDs), and provide medical professionals and management with quantitative data so th ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. Development of novel and stable glucagon formulations for closed loop systems

    SBC: Biodel Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): A device system which automatically maintain blood glucose concentrations in the normal range by dosing insulin in response to continuously sensed glucose concentration data represents a modern attempt to mechanically simulate normal beta cell physiology and solve many of the problems associated with intensive insulin therapy today, including improving the qual ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. Development of concentrated and rapidly absorbed insulins for closed loop systems

    SBC: Biodel Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Extreme insulin resistance in patients with diabetes is defined as insulin dose requirement of greater than 200 units daily. Currently, U-500 regular insulin is frequently used to treat these patients, however, the slowabsorption and prolonged duration of action associated with this formulation does not lend itself to effective closed loop insulin pump therapy. ...

    SBIR Phase I 2012 Department of Health and Human Services
  9. Functional phenotyping of leukocyte reprogramming in Type 1 diabetes

    SBC: CIENCIA INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States Source ADA http://www.diabetes.org/about-diabetes.jsp and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention for T1D is on the detection and characterization of auto-reactive T cells, which play a central role ...

    SBIR Phase I 2012 Department of Health and Human Services
  10. Paramagnetic Microbead-based Surface Plasmon Microarray Detection of Toxins and T

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION (provided by applicant): The proposed work will result in a characterized prototype instrument that will facilitate the identification of a broad range of analytes in small volumes of human blood, urine, saliva and other readily obtainable biological fluids with little sample preparation. The proposed instrument will incorporate two related analytical approaches, grating-coupled surfac ...

    SBIR Phase I 2012 Department of Health and Human Services

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