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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Dynamic Non-Contact 3D Measurement System for Rollover Testing

    SBC: Photon-x, Inc.            Topic: 07NH2

    During Phases I and II, Photon-X successfully demonstrated the feasibility of applying its patented Spatial Phase Imaging technology to the problem of non-contact 3D imaging during a rollover test and delivered a viable prototype system. During Phase IIB, Photon-X will continue to refine the system in preparation for commercialization. Photon-X will use this opportunity to add an additional camer ...

    SBIR Phase II 2012 Department of Transportation
  2. Locating the Elderly Overseen by Nurses- LEON

    SBC: Q-Track Corporation            Topic: NIA

    DESCRIPTION (provided by applicant): The proposed effort aims to develop a comprehensive wireless tracking and monitoring system for residents of Long Term Care facilities. The commercial product ElderAlertTM extends Q-Track's real-time location system totrack residents, caregivers, and medical assets within a LTC facility. ElderAlertTM directs caregivers to residents who have fallen or have ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. A NOVEL MICROFLUIDIC DEVICE FOR SELECTION AND OPTIMIZATION OF DRUG DELIVERY VEHIC

    SBC: CFD Research Corporation            Topic: NCI

    DESCRIPTION (provided by applicant): We propose to develop and demonstrate a novel microfluidic device and assay for selection and optimization of delivery vehicles, specifically non-viral vectors for drug delivery to tumors. Tumor drug delivery is a complex phenomenon affected by several elements in addition to drug or delivery vehicle's physico-chemical properties. A key factor is tumor mic ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. New In Vitro Human Liver Toxicity Bioassay System

    SBC: Vivo Biosciences Inc            Topic: NIEHS

    DESCRIPTION (provided by applicant): The overall objective of this SBIR proposal is to develop and commercialize a human 3D or mini- liver bioassay system suitable for real-time analysis of metabolic functions and long-term drug toxicity profiles. At present, liver functions are mostly studied using HepG2 cell line and primary hepatocytes cultured onto collagen or polymer matrices. However, these ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. A novel physiologically realistic microfluidic in-vitro blood-brain barrier model

    SBC: CFD Research Corporation            Topic: NIGMS

    DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast to current in-vitro models, our proposed device, SIM-BBB, comprises of a microfluidic two-compartment chamber. The chamber is designed in such a way as to permit vis ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Electronic Location Reporting for Individuals With Cognitive Disabilities

    SBC: INTELLISPEAK, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Mitochondrial DNA repair agents for acute lung injury

    SBC: EXSCIEN CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Drug development for acute lung injury (ALI) has been marred by unfulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the history of therapeutic strategies directed at inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire ...

    STTR Phase I 2012 Department of Health and Human Services
  8. Delivery system development for a reservoir targeted Lyme disease vaccine

    SBC: FoodSource Lure Corporation            Topic: NIAID

    DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tickvector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme di ...

    STTR Phase II 2012 Department of Health and Human Services
  9. Optimization of Protein Therapeutics Formulations

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This proposal involves the development of a high-throughput self-interaction chromatography (SIC) system that will be used by Soluble Therapeutics, LLC, to improve and accelerate the formulation discovery process for biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infect ...

    STTR Phase II 2012 Department of Health and Human Services
  10. A non-invasive high-throughput sleep stage analysis system

    SBC: Pinnacle Technology, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): Degeneration of sleep quality with age is a well-documented phenomenon. While much is known regarding the characterization of this decline, remarkably little of the physiology or genetic underpinnings are understood. Age-related sleep changes in rodents (mice + rats) are remarkably similar to those seen in human populations and as such these animal models are f ...

    SBIR Phase I 2012 Department of Health and Human Services

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