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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Electronic Location Reporting for Individuals With Cognitive Disabilities

    SBC: INTELLISPEAK, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Piezoelectric Pipetting for High Density Nucleic Acid Programmable Protein Arrays

    SBC: ENGINEERING ARTS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Among the currently available techniques for high throughput proteomics, protein microarrays have the greatest prospects to revolutionize molecular diagnostics for early detection, diagnosis, treatment, prognosis and monitoring clinical response. However, protein microarrays have yet to reach their full potential as a research or clinical molecular diagnostics ...

    STTR Phase II 2012 Department of Health and Human Services
  4. A non-invasive high-throughput sleep stage analysis system

    SBC: Pinnacle Technology, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): Degeneration of sleep quality with age is a well-documented phenomenon. While much is known regarding the characterization of this decline, remarkably little of the physiology or genetic underpinnings are understood. Age-related sleep changes in rodents (mice + rats) are remarkably similar to those seen in human populations and as such these animal models are f ...

    SBIR Phase I 2012 Department of Health and Human Services
  5. Electronic Location Reporting for Individuals With Alzheimers Disease and other D

    SBC: INTELLISPEAK, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the evaluation of a wireless electronic location system for reporting the location of individuals with Alzheimer's Disease and other Dementia (ADOD), who tend to wander or elope. This isa very vexing and routine problem for caregivers, and sometimes results in physical danger and emotional stress to the individuals who may ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Control Your Cravings: A Web-Based Transdiagnostic Self-Management Program

    SBC: GOALISTICS, LLC            Topic: NIDA

    DESCRIPTION (provided by applicant): Craving, when viewed as a compelling desire to consume a potentially harmful substance or to engage in a potentially harmful act, has been increasingly targeted for basic research, clinical assessment, and treatment. The management of cravings is a critical component of treatment for self- regulatory problems such as substance and alcohol abuse, overeating, gam ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. A Nicotine Biosensor for Addiction Studies

    SBC: Pinnacle Technology, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Tobacco-related deaths cost the United States approximately 200 billion each year. Nicotine is singularly responsible for the dependence-forming properties of tobacco smoking and, once introduced to the body, rapidly affects the brain within 15 seconds. Breaking nicotine addiction is challenging and relapse rates remain high. The extremely rapid timescale of n ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. Precision Particle Fabrication-enabled Betamethasone-loaded Microspheres for Tran

    SBC: ORBIS BIOSCIENCES, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Current approaches to treat sudden sensorineural hearing loss (SSNHL) do not maintain inner ear drug concentrations within an appropriate therapeutic window for sufficient lengths of time to achieve therapeutic effect.A novel delivery system for long-term, controlled release of glucocorticoid steroids to the inner ear would constitute a dramatic improvement in ...

    SBIR Phase I 2012 Department of Health and Human Services
  9. HAZworker- Web-Based, Multiplayer Small Group Simulation

    SBC: Inxsol LLC            Topic: NIEHS

    DESCRIPTION: Project Summary inXsol proposes to design and demonstrate a web-based, multiplayer small group simulation to support instructor led HazMat worker health and safety training. This product is called HAZworker. The use of distributed, low-cost simulation will allow individuals to attain a level of experience in the probable roles at typical incidents and work sits and to receive the nece ...

    SBIR Phase I 2012 Department of Health and Human Services
  10. Engineering Microparticles for Taste-Masking and Controlled Release of Pediatric

    SBC: ORBIS BIOSCIENCES, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): Pediatric drug development presents many unique challenges in the effective treatment of diseases in children, from adequate dosing information and pediatric-specific testing to palatable flavor profiles and effective delivery formats. A novel technology that masks bitter drug flavors while providing flexibility in dose design and format would enable formulati ...

    SBIR Phase I 2012 Department of Health and Human Services

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