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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Therapeutic Inhibition of MIF in Rheumatoid Arthritis

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): The long-term product goal of this project is a small molecule therapeutic to treat rheumatoid arthritis (RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). Since MIF is an upstream regulator of the inflammatory cascade, small molecule therapeutics targeting MIF activity ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Electronic Location Reporting for Individuals With Cognitive Disabilities

    SBC: INTELLISPEAK, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Measurement of Beta Cell Death in Diabetes

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose islet or pancreas allografts. New therapies have been developed that can modulate the course of T1D but the effective appli ...

    STTR Phase I 2012 Department of Health and Human Services
  4. Computational Tools for Research in Neuroscience, Behavioral Science and Mental H

    SBC: Molecular Neuroimaging, L.l.c.            Topic: NINDS

    DESCRIPTION (provided by applicant): We propose to develop a software package to automatically evaluate a subject's beta amyloid PET scan (using either C11-PIB, F18-florbetaben, or F18-florbetapir, F18-flutemetamol) by normalizing the subject's scan, masking away non-gray matter tissue (without relying on co-registered MRI scans), placing standardized ROIs onto the transverse slices, and ...

    STTR Phase II 2012 Department of Health and Human Services
  5. A non-invasive high-throughput sleep stage analysis system

    SBC: Pinnacle Technology, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): Degeneration of sleep quality with age is a well-documented phenomenon. While much is known regarding the characterization of this decline, remarkably little of the physiology or genetic underpinnings are understood. Age-related sleep changes in rodents (mice + rats) are remarkably similar to those seen in human populations and as such these animal models are f ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Electronic Location Reporting for Individuals With Alzheimers Disease and other D

    SBC: INTELLISPEAK, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the evaluation of a wireless electronic location system for reporting the location of individuals with Alzheimer's Disease and other Dementia (ADOD), who tend to wander or elope. This isa very vexing and routine problem for caregivers, and sometimes results in physical danger and emotional stress to the individuals who may ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 38,000 confirmed and probable cases reported to the CDC in 2009. Spirochetes first establish infection in the skin and then disseminate to internal organs such as the heart, the joints, and the ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. Hsp90 inhibitors to combat antifungal drug resistance.

    SBC: LIFEPHARMS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Fungal infections continue to be a major cause of morbidity and mortality among HIV-infected patients. Many of the emerging fungal pathogens that are resistant to the three classes of antifungal agents for AID-s-relatedinfections are becoming more common and are associated with higher rates of mortality. Combating drug resistant fungal pathogens should be a top ...

    SBIR Phase I 2012 Department of Health and Human Services
  9. Saliva Analyzer for Diagnosing SRD Patient Drug Use

    SBC: REAL-TIME ANALYZERS, INCORPORATED            Topic: NIDA

    DESCRIPTION (provided by applicant): The overall aim of this SBIR program is to develop a surface-enhanced Raman spectroscopy (SERS) based device for on-site analysis of drugs in saliva. This device will allow immediate assessment of both medicinal and illicit drug use by patients with substance-related disorders (SRDs), and provide medical professionals and management with quantitative data so th ...

    SBIR Phase I 2012 Department of Health and Human Services
  10. A Nicotine Biosensor for Addiction Studies

    SBC: Pinnacle Technology, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Tobacco-related deaths cost the United States approximately 200 billion each year. Nicotine is singularly responsible for the dependence-forming properties of tobacco smoking and, once introduced to the body, rapidly affects the brain within 15 seconds. Breaking nicotine addiction is challenging and relapse rates remain high. The extremely rapid timescale of n ...

    SBIR Phase I 2012 Department of Health and Human Services

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