Award Data

This project develops a technology solution to address the indoor navigation needs experienced by people with visual disabilities. This technology has several advantages over other wayfinding approaches such as GPS, in that it requires no infrastructure in indoor spaces nor does it require maps to be created prior to navigation. Thus, it is applicable to any unfamiliar indoor or outdoor space. The ...

Healthy design features in a workplace can enable healthy eating and physical activitywhich are key behaviors in the prevention of obesity and other chronic diseasesAs of yetthere is no comprehensive webbased tool for designers and employers in different types of workplacesparticularly small business settingsto learn about and implement behavioral design strategies in the workplaceThe goal of this ...

The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

There is growing interest in the study of RNA modifications and its potential role(s) in many physiological abnormalities, such as modulating many processes associated with cancer development and progression. While RNA sequencing (RNA-seq) using short-read nextgeneration sequencing (NGS) have proven to be a useful tool for identifying specific RNA modifications, there still remains technical chall ...

PROJECT SUMMARYHistone methyltransferasesHMTsare a group of enzymes that represent a critical focal point in the linkage of cellular signals to the regulation of gene expressionThese proteins are not only strongly associated with numerous diseasese gcancersneurodegenerative diseasesand autoimmune disordersbut also have properties that make them excellent targets for drugsThusHMTs provide an except ...

Project SummaryAmong the commercially available systems for single cell isolation and next generation sequencingNGSsample preparationnone are capable of automating both imaging and NGS sample preparation at high throughputWhile single cell genomic analysis has improved in sensitivity and throughputconcomitant improvements in detailed phenotypic characterization of cells has not been integrated int ...

AbstractThe prolific worldwide misuse of organophosphateOPpesticidescoupled with a grave homeland security concern that OP based nerve agents may be deployed either against our troops or civilians on our home soilhas stimulated the search for rapidminiaturized and inexpensive point of carePOCdiagnostic devices for first responders and medical personnel to detect the degree of OP exposureIdentifica ...

The global contraceptives market was valued at $billion inand is expected to grow at a CAGR offromtoto reach an estimated value of $billion inThe contraceptive market consists of short term methods such as condoms and oral contraceptionlong term methods including implants and IUDsand permanent methods such as tubal ligations and vasectomiesEppin Pharmaandapos s product has a unique set of characte ...

Project SummaryOver $billion is spent annually in the US treating chronicnon healing woundsmany of which face lifethreatening complications due to infectionsWound infections are difficult to treat due to the frequency of antibiotic resistance as well as the formation of biofilmsa community of bacteria covered by an extracellular polymeric substanceBiofilm related infections can result in a substan ...

Abstract This project seeks to develop the next generation pro CARs that are inactive in normal tissues but selectively activated in the tumor microenvironmentTMEThe project is based on our previous development of a novel class of chimeric antigen receptors on the basis of single domain antibody mimics that recognize ErbB family membersSDAErbBon the surface of cancer cellsWe propose two specific a ...