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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Viability of Crowd-Source Transit Information Systems

    SBC: View Update Media LLC            Topic: 121FT1

    The company is commercializing a mobile social computing system named Tiramisu (“pick me up” in Italian) that is intended to connect riders and transit service providers. It supports a variety of collaboration mechanisms designed to improve the experience of riders in a transit service and improve the service provided by service operators. The system has been designed using current knowledge i ...

    SBIR Phase I 2012 Department of Transportation
  2. Individualized Fatigue Management Program Technology for Trucking Operations

    SBC: PULSAR INFORMATICS, INC.            Topic: 091FM1

    Individual differences in vulnerability to sleep loss and fatigue from extended work hours and night work are a substantial problem in transportation policy making, work schedule development, fatigue risk management strategies, and prediction of performance impairment in real-world operations (Van Dongen et al. 2003; Mollicone et al. 2010). Our group was the first to document the considerable magn ...

    SBIR Phase II 2012 Department of Transportation
  3. RAIL reduces variability and concentration of stress hormones in blood sampling

    SBC: ACTUATED MEDICAL, INC.            Topic: NIA

    DESCRIPTION (provided by applicant): In this Phase II SBIR, Actuated Medical, Inc. (f/k/a Piezo Resonance Innovations, Inc) will complete the development of the Resonance Assisted Insertion Lancet (RAIL ) System to reduce animal pain and stress response during laboratory animal blood sampling. Public Health Problem: Understanding the physiological and biological mechanisms of aging is the focus o ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Defining T cell epitopes in Dengue virus infection

    SBC: IMMUNOTOPE, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): There is a well-recognized need to develop vaccines that stimulates humoral immunity as well as a potent T cell immunity in order to achieve protection from infection with pathogens. Although numerous investigations arefocused on developing vaccines that induce protective humoral responses, only a few studies are aimed towards developing specific T cell immunit ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Portable electronically controlled transdermal patch for enfuvirtide delivery

    SBC: ACTUATED MEDICAL, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): In this Phase II NIH SBIR, Piezo Resonance Innovations will further optimize and test the Portable Transdermal Patch (PTP) - a needle-free platform delivery technology for drugs and vaccines that are currently deliveredsubcutaneously. The portable, 200gm (7oz) electronically-controlled transdermal patch for Enfuvirtide delivery employs a patented transducer tec ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib

    SBC: PolyMedix, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Malaria is a global disease causing gt 500 million clinical cases and gt 1 million deaths each year. Moreover, drug resistant Plasmodium falciparum has become a major problem. Therefore, it is crucial to discover new classes of drugs for anti-malarial drug design to combat resistant parasites. We propose that antimicrobial peptides (AMPs) may provide the basis ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. A novel fluorescent assay for ubiquitin isopeptide bond cleavage

    SBC: LIFESENSORS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): In the last decade there has been an explosive growth in the field of ubiquitin research, with approximately 530 human genes predicted to encode enzymes involved in the conjugation and deconjugation of ubiquitin. Of these 95 encode for deubiquitylases (DUBs). In order understand the biology of these enzymes better, there is a need for better assays to measure t ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Research and Deployment of a quantum mechanical NMR tool for fragment based drug

    SBC: QuantumBio, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Improving human health by enabling the development of drugs faster and cheaper is an important part of the NIH mission. This is partially achieved by introducing and constantly improving enabling technologies. One suchtechnology is structure based drug design. Determining the structure of a small molecule (drug candidate or lead compound) to a biological recept ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Electronic Location Reporting for Individuals With Cognitive Disabilities

    SBC: INTELLISPEAK, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. Novel Modulators of HDL Metabolism

    SBC: Shifa Biomedical Corporation            Topic: NHLBI

    Project Summary/Abstract Cardiovascular disease remains the leading cause of morbidity and mortality for both men and women, accounting for nearly 40% of annual deaths. High levels of LDL-C and low levels of HDL-C are well-known risk factors for heart disease. Although lowering low-density lipoprotein cholesterol (LDL-C) levels using a number of marketed drugs, of which statins are the leading dr ...

    SBIR Phase II 2012 Department of Health and Human Services

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