List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of NMUR2 Antagonists as Novel Analgesics

    SBC: OMEROS CORPORATION            Topic: NIDA

    DESCRIPTION (provided by applicant): Pain affects over 100 million Americans annually. Opioids are the primary drugs that can treat pain. However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008); in addition, they are highly addictive (Koob et al, 1998). There is clearly a large, unmet need for ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Overcoming Tramadol Resistance In CYP2D6 Poor Metabolizers

    SBC: Syntrix Biosystems, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Tramadol is a widely prescribed analgesic, with over 25 million prescriptions and 565 million in retail sales in 2009, making it among the best selling generic drugs. One of the advantages of tramadol over traditionalopioids is its lower risk of opioid dependence, resulting in it having an unscheduled status in the U.S. and other countries. Although its mode ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. A Personal Monitor for Space- and Time-Resolved Measurements of Aerosol Exposure

    SBC: ENERTECHNIX, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): The proposed project will develop and demonstrate a miniaturized, portable aerosol sampler that will collect a series of time- and location-resolved personal exposure samples for conducting research into the relationships among environmental exposure, genetics and health. It will also develop a bench-top assay unit that will perform colorimetric assays for endo ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Phase Plate Holder for Transmission Electron Microscopy

    SBC: Hummingbird Precision Machine Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): At the frontier of biological electron microscopy, there is a strong emphasis on imaging the 3-D structure of cells, organelles, and macromolecules in their native state. This is facilitated by the use of frozen-hydrated specimens which have not been subjected to chemical fixation, dehydration or stains. The resolution is currently limited to about 4 nm by ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Anti-Infective Dermal Integration Sleeves for Needle Free Dialysis Access Devices

    SBC: HEALIONICS CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Significance: End Stage Renal Disease (ESRD) affects a rapidly growing population likely to exceed 1 million patients in the US by 2020. The standard treatment of 3 times per week hemodialysis (HD) has high complicationrates and infection risks, results in undertreated patients, and is unsustainably costly to the health care system. Conventional vascular access ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Electronic Location Reporting for Individuals With Cognitive Disabilities

    SBC: INTELLISPEAK, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Efficient patient-specific cell generation by image-guidance

    SBC: DRVISION TECHNOLOGIES LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): This fast-track proposal applies advanced kinetic image pattern recognition (KIPR) technologies to predict induced pluripotent stem cell (iPSC) reprogramming colonies' differentiation outcomes for significantly improvedyield and robustness of differentiation protocols. The objectives of the proposed tool are 1) Teaching: creation of scores for induced colo ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Testing of novel system to deliver VRC01 in mouse model

    SBC: Immusoft Corporation            Topic: NIAID

    DESCRIPTION (provided by applicant): HIV/AIDS is a global epidemic afflicting more than 33 million people worldwide. HIV can often be suppressed for many years with anti-retroviral medications, and over 15 billion dollars were spent on these medications in2010. Biologics such as HIV-1 neutralizing antibodies (NAbs) VRC01, PG9, and b12 and peptides such as Enfuvirtide are potent inhibitors of HIV a ...

    STTR Phase I 2012 Department of Health and Human Services
  9. Antigen Detection Assay for the Diagnosis of Melioidosis

    SBC: Inbios International Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis. The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding. Melioidosis is difficult to trea and diagnose due to the fact that B. pseudomallei is resistant to common antibiotics and symptoms are non-specific. Morta ...

    STTR Phase I 2012 Department of Health and Human Services
  10. A novel therapeutic strategy for Acute Lung Injury: Inhibition of PKC-delta

    SBC: COMPLEGEN, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Sepsis and the related systemic inflammatory response are the leading causes of death in intensive care units. More than 200,000 people die each year in the US from sepsis and associated complications. The lung is the organ most often affected with pulmonary dysfunction resulting in acute lung injury (ALI) or the more severe acute respiratory distress syndrome ...

    STTR Phase I 2012 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government