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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of NMUR2 Antagonists as Novel Analgesics

    SBC: OMEROS CORPORATION            Topic: NIDA

    DESCRIPTION (provided by applicant): Pain affects over 100 million Americans annually. Opioids are the primary drugs that can treat pain. However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008); in addition, they are highly addictive (Koob et al, 1998). There is clearly a large, unmet need for ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Overcoming Tramadol Resistance In CYP2D6 Poor Metabolizers

    SBC: Syntrix Biosystems, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Tramadol is a widely prescribed analgesic, with over 25 million prescriptions and 565 million in retail sales in 2009, making it among the best selling generic drugs. One of the advantages of tramadol over traditionalopioids is its lower risk of opioid dependence, resulting in it having an unscheduled status in the U.S. and other countries. Although its mode ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  3. BIOMARKER FOR EARLY DETECTION OF CHRONIC KIDNEY DISEASE

    SBC: SEQUELA, INCORPORATED            Topic: NIDDK

    DESCRIPTION (provided by applicant): There are an estimated 26 million Americans with early chronic kidney disease (CKD). Early diagnosis and treatment are the only cost-effective means to reverse this growing problem. NIH recognizes the challenge to diagnose CKD early during its initiation and development phases in order to prevent further renal damage, reduce cardiovascular risk, and minimize th ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  4. A Personal Monitor for Space- and Time-Resolved Measurements of Aerosol Exposure

    SBC: ENERTECHNIX, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): The proposed project will develop and demonstrate a miniaturized, portable aerosol sampler that will collect a series of time- and location-resolved personal exposure samples for conducting research into the relationships among environmental exposure, genetics and health. It will also develop a bench-top assay unit that will perform colorimetric assays for endo ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  5. Phase Plate Holder for Transmission Electron Microscopy

    SBC: HUMMINGBIRD PRECISION MACHINE CO.            Topic: NIGMS

    DESCRIPTION (provided by applicant): At the frontier of biological electron microscopy, there is a strong emphasis on imaging the 3-D structure of cells, organelles, and macromolecules in their native state. This is facilitated by the use of frozen-hydrated specimens which have not been subjected to chemical fixation, dehydration or stains. The resolution is currently limited to about 4 nm by ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  6. Enhancing mammalian glycoprotein production in the baculovirus expression vector

    SBC: PARATECHS CORP            Topic: NIGMS

    DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) is a proven, powerful and versatile method of eukaryotic protein expression. It is used to produce vaccines, diagnostics, and biologically active proteins for a multitudeof research projects. Like all expression systems, however, BEVS has its disadvantages. One is the fact that expression is short-lived due to vir ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  7. Anti-Infective Dermal Integration Sleeves for Needle Free Dialysis Access Devices

    SBC: HEALIONICS CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Significance: End Stage Renal Disease (ESRD) affects a rapidly growing population likely to exceed 1 million patients in the US by 2020. The standard treatment of 3 times per week hemodialysis (HD) has high complicationrates and infection risks, results in undertreated patients, and is unsustainably costly to the health care system. Conventional vascular access ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  8. FastFES Neural Prothesis for Stroke Ambulation and Rehabilitation

    SBC: CUSTOMKYNETICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): This FastTrack SBIR proposal aims to disseminate a Functional Electrical Stimulation (FES) technology for stroke ambulation and neuromotor rehabilitation. The FastFES paradigm integrates two rehabilitation approaches,fast-paced treadmill walking and FES, in a manner that has been shown to both improve gait kinematics when the stimulation is active and to impro ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Electronic Location Reporting for Individuals With Cognitive Disabilities

    SBC: INTELLISPEAK, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  10. Counterpulsation Device with Integrated EKG System for Chronic Partial Circulator

    SBC: SCR, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Heart failure (HF) remains one of the largest unsolved problems in health care today and continues to increase in incidence and cost ( 34.8 billion in US in 2008). Prognosis remains limited especially in patients with advanced heart failure. Transplantation is often the best option for patients with advanced HF whose hearts are not recoverable but is limited by ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
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