Award Data

DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

DESCRIPTION (provided by applicant): Degeneration of sleep quality with age is a well-documented phenomenon. While much is known regarding the characterization of this decline, remarkably little of the physiology or genetic underpinnings are understood. Age-related sleep changes in rodents (mice + rats) are remarkably similar to those seen in human populations and as such these animal models are f ...

DESCRIPTION (provided by applicant): The proposed effort is aimed at the evaluation of a wireless electronic location system for reporting the location of individuals with Alzheimer's Disease and other Dementia (ADOD), who tend to wander or elope. This isa very vexing and routine problem for caregivers, and sometimes results in physical danger and emotional stress to the individuals who may ...

DESCRIPTION (provided by applicant): Tobacco-related deaths cost the United States approximately 200 billion each year. Nicotine is singularly responsible for the dependence-forming properties of tobacco smoking and, once introduced to the body, rapidly affects the brain within 15 seconds. Breaking nicotine addiction is challenging and relapse rates remain high. The extremely rapid timescale of n ...

DESCRIPTION (provided by applicant): Current approaches to treat sudden sensorineural hearing loss (SSNHL) do not maintain inner ear drug concentrations within an appropriate therapeutic window for sufficient lengths of time to achieve therapeutic effect.A novel delivery system for long-term, controlled release of glucocorticoid steroids to the inner ear would constitute a dramatic improvement in ...

DESCRIPTION (provided by applicant): Pediatric drug development presents many unique challenges in the effective treatment of diseases in children, from adequate dosing information and pediatric-specific testing to palatable flavor profiles and effective delivery formats. A novel technology that masks bitter drug flavors while providing flexibility in dose design and format would enable formulati ...

DESCRIPTION (provided by applicant): The aim of this application is to develop, prototype, validate, manufacture and commercialize a new, generalized microbiosensor designed for non-human use and based on functionalized nanoparticles. The microbiosensors produced will enable in vivo monitoring of a wide range of non-electroactive, neurologically relevant analytes, including, but not limited to, gl ...

A RAPID FIELD TEST IS PROPOSED TO EVALUATE THE PERMEABILITY OF OPEN-GRADED ROAD BASES AND OTHER DRAINAGE LAYERS. THE SAME TEST ALSO SHOULD BE ADAPTABLE TO EVALUATE PERMEABILITIES OF OTHER EXPOSED PAVEMENT LAYERS INCLUDING THOSE COMPOSED OF BITUMINOUS OR PORTLAND CEMENT CONCRETES, AS AN INDEX TO PERMEATION AND POSSIBLY TO DETERIORATION. IT IS PROPOSED THAT THE PERMEABILITY BE EVALUATED THROUGH USE ...

THE PROPOSED PROJECT WILL DETERMINE THE FEASIBILITY OF THE USE OF ADVANCED TYPE II FLUIDS FOR THE DE-ICING/ANTI-ICING OF GENERAL AVIATION (GA) AIRCRAFT WITH TAKEOFF SAFETY SPEEDS (V2) OF GENERALLY LESS THAN 85 KNOTS. TYPE II FLUIDS WILL BE APPLIED TO SEVERAL GA CATEGORY AIRCRAFT. THE ICE PROTECTION CAPABILITY OF THE FLUID WILL BE EVALUATED FOR DIFFERENT FREEZING PRECIPITATION CONDITIONS. THE EFFEC ...

THE AIM OF THIS PROJECT IS TO EVALUATE THE FEASIBILITY OF DEVELOPING ANALYTICAL TECHNOLOGY APPLICABLE TO THE DETERMINATION OF DESMOSINE (DMS) IN THE SYSTEMATIC CIRCULATORY SYSTEM AND IN OTHER PHYSIOLOGICAL SAMPLES. IN VIVO HYDROLYTIC DEGRADATION OF THE CONNECTIVE TISSUE ELASTINBY THE ENZYME ELASTASE PRODUCES DMS-PEPTIDE FRAGMENTS. CURRENT RESEARCH SUGGESTS THAT AN ACCURATE DETERMINATION OF DMS-PEP ...