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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Non-Destructive Test Method for Rapid Determination of the Chemical Composition of Concrete in Field

    SBC: METNA CO            Topic: 122FH2

    While thorough assessment of concrete chemistry is vital to evaluating the health of (transportation) infrastructure systems, the costly and time-consuming nature of available chemical analysis methods limit their applications. A nondestructive test method will be developed for thorough evaluation of concrete chemistry and deterioration conditions at different depths. An analytical chemistry metho ...

    SBIR Phase I 2012 Department of Transportation
  2. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION

    SBC: ORIGINUS, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated inat least an in vitro system. Enzymatic activity in freshly isolated hepatocytes is the Gold Standard for studying P450 induction; however, it ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. An Antisense Design and Simulation Platform

    SBC: DNA SOFTWARE, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of antisense technologies to the study of human diseases has been proven in the literature for cancer, im ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients

    SBC: Integrated Sensing Systems Incorporated            Topic: NHLBI

    DESCRIPTION (provided by applicant): Congenital heart disease patients with functional single ventricle (FSV) anatomy usually require a series of surgeries during infancy and childhood in order to provide them with a chance to survive into adulthood. The second stage surgery, termed the hemi-Fontan procedure (HFP) re-routes systemic venous blood from the upper body and head into the pulmonary circ ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome

    SBC: Innovative Biotherapies, Inc.            Topic: NCATS

    DESCRIPTION (provided by applicant): Leukocytes (LE) are major contributors to the pathogenesis and progression of many clinical inflammatory disorders, including the systemic inflammatory response syndrome, sepsis and acute respiratory distress syndrome.The need for new and innovative therapies to treat these inflammatory disease states presents a large commercial market opportunity. A large numb ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. High Throughput 3D Cell Assay for Metastatic Prostate Cancer

    SBC: 3D BIOMATRIX, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Prostate cancer is the most common non-skin cancer in United States men. Despite recent advances, prostate cancer mortality still remains high due to the emergence of therapy-resistant cancer cells that metastasize. This lack of effective therapies against metastatic cancer exists, at least in part, because of lack of drug screening platforms that address the u ...

    STTR Phase I 2012 Department of Health and Human Services
  7. Doppler Window for Low-Cost High-Performance Vascular Imaging

    SBC: ARBOR ULTRASOUND TECHNOLOGIES, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): This proposal describes a novel, low-cost, high-performance hand-held Doppler ultrasound imaging system to meet the clinical needs from simple vessel location to advanced vascular diagnostic techniques such as elasticity imaging. This research proposal integrates proven fundamental techniques with modern technology. The proposed device revisits original ultraso ...

    STTR Phase I 2012 Department of Health and Human Services
  8. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board

    SBC: VIDATAK, LLC            Topic: NINR

    DESCRIPTION (provided by applicant): Effective communication between patients and healthcare professionals is important for positive clinical outcomes. However, patients with special communication handicaps [e.g., limited English proficiency, hearing impairment, aphasia, intubation for mechanical ventilation (MV)] have a limited number of tools to help them communicate their needs and physical sta ...

    STTR Phase I 2012 Department of Health and Human Services
  9. Development of flow and vascular quantification software for the assessment of MR

    SBC: Magnetic Resonance Innovations, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): There has been a huge increase in demand for comprehensive quantitative analysis of neurovascular imaging data produced in the clinical setting for diseases such as multiple sclerosis, traumatic brain injury, stroke anddementia. Our objective in this project is to design and develop advanced image processing software that can rapidly and accurately analyze such ...

    STTR Phase I 2012 Department of Health and Human Services
  10. Advancing patient call light systems to achieve better outcomes

    SBC: Patient Provider Communications, Inc.            Topic: NIMHD

    DESCRIPTION (provided by applicant): Current nurse call systems lack patient-centric interfaces (i.e. pillow speakers) and the ability to relay specific requests to the most appropriat providers, which negatively impacts operational efficiency. Further, existing systems neither provide a means for limited English proficiency (LEP) patients to make call requests in their native language nor the abi ...

    STTR Phase II 2012 Department of Health and Human Services

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