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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Oral transmucosal drug delivery system for naltrexone

    SBC: BIONEX PHARMACEUTICALS LLC            Topic: NIAAA

    DESCRIPTION (provided by applicant): The proposed SBIR Phase II project aims at developing a new drug product, the naltrexone orally dissolving film (ODF), for treatment of alcohol dependence. The naltrexone ODF is a small, thin, and flexible film, containing naltrexone hydrochloride and other excipients. It is applied intra-orally and adheres to the oral mucosa to affect a rapid onset of action d ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Arm Motor Rehabilitation, Entertainment and Cognition System for the Elderly

    SBC: Bright Cloud International Corp            Topic: NIA

    DESCRIPTION (provided by applicant): It is hypothesized that the use robotic rehabilitation tables coupled with virtual reality games with elderly stroke survivors residents in skilled nursin facilities (SNFs) will: 1) improve and maintain upper extremityuni-manual and bimanual function, reach, strength and ADL independence; 2) improve and maintain cognition (memory, focus, problem solving); and ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Protein Therapeutics for Muscular Dystrophy

    SBC: TRIM-EDICINE, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): SBIR 1R43AR060019 Phase II application: Protein Therapeutics for Muscular Dystrophy Principal Investigator: Takizawa, Norio Project Summary: This application requests for a Phase II project for our initial SBIR grant addressing the use of a novel protein therapeutic agent, MG53, for the treatment of muscular dystrophy (1R43AR060019). Our Phase I studi ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Off-the-shelf Dental Regeneration Technologies

    SBC: INNOVATIVE ELEMENTS, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to per ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Enabling Technology to Prepare Ultrapure Dialysate in Dialysis Clinics

    SBC: NOVAFLUX TECHNOLOGIES, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The clinical significance of chronic pro-inflammatory reactions in dialysis patients due to exposure to endotoxin has become a central issue in nephrology. The European Renal Association urges the routine use of ultrapure dialysate with bacteria and endotoxin levels of lt 0.1 CFU/ml and lt 0.03 EU/ml, respectively. In the US, the maximum allowable limit of ba ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Point-of Care System for Determination of Bilirubin Capacity in Neonates

    SBC: AVIV BIOMEDICAL INC            Topic: NIBIB

    DESCRIPTION (provided by applicant): Uncontrolled hyperbilirubinemia (jaundice) in neonates has long been known to lead to neurological dysfunction including irreversible athetoid cerebral palsy with speech, ocular and hearing impairments, and even death.Contemporary management is based upon monitoring the total serum bilirubin (TBS), taking into account other clinical parameters such as birth wei ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Tagging of Histopathology Specimens with Light-Activated RFID p-Chips

    SBC: PHARMASEQ, INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The purpose of the present project is to develop and validate the use of ultra-small RFID chips to tag and track tissue cassettes and glass slides that are used in histopathology laboratories. The system is based on thePharmaSeq laser light-activated microtransponder, also known as p-Chip . The chip's major advantages are its small size (500 m x 500 m ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Acute Ischemia Monitor Utilizing Subcutaneous Electrodes

    SBC: ANGEL MEDICAL SYSTEMS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): This project consists of the research and development of a unique implantable ischemia monitor that uses subcutaneous sensors in the patient's torso to detect the onset of acute myocardial infarction (AMI). Upon detecting a heart attack, the monitor generates an alarm, which enables the patient to promptly seek medical treatment. In the United States, the ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Development of a FISH-Based HPV-Associated Cancer Detection Test

    SBC: Gentris Corporation            Topic: NCI

    DESCRIPTION (provided by applicant): A causative role of high-risk human papillomavirus (HPV) types in human cancer has been established, particularly for those of the anogenital region including cervical and anal cancers. The etiologic course of such cancers is thought to involve HPV infection, persistence of infection, progression to an immediate precursor of cancer, and finally invasion (the la ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. Targeting B-cell lymphoma with Leukothera

    SBC: ACTINOBAC BIOMED, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): B-cell lymphomas include Hodgkin's, and non-Hodgkin's lymphoma (NHL) (eg. mantle cell lymphoma (MCL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma). More than 70,000 people willbe diagnosed with these B-cell malignancies in the U.S. this year and more than 19,000 will die from NHL alone. B-cell lymphomas can af ...

    STTR Phase I 2012 Department of Health and Human Services

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