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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ABLE Kids II- Advanced Biofidelic Lower Extremity Kids Prosthesis II

    SBC: Orthocare Innovations LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): The Advanced Biofidelic Lower Extremity Kids prosthesis (ABLE Kids) project will advance the state-of-the-art of pediatric prosthesis systems by advancing the demonstrably successful Phase I device and refining it intoan ultracompact and lightweight form factor suitable for pediatric use. Through the support of the Shriner's Hospitals in Salt Lake City, U ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Computerized Orthotic Prescription System- COPS

    SBC: Orthocare Innovations LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): Stiffness and alignment of ankle-foot orthoses (AFOs) should be tuned optimally to maximize their function. Improperly tuned AFO may induce joint pain, reduced ambulatory function, and increased medical complications for patients with stroke. Therefore, the relative quality of AFOs fit determined by its stiffness and alignment is of paramount concern in the d ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Development of an Anti-P-selectin Antibody for the Treatment of Sickle Cell Disea

    SBC: SELEXYS PHARMACEUTICALS CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Selexys Pharmaceuticals is developing a humanized monoclonal antibody drug called SelG1 directed against P-selectin for the treatment of vasoocclusive crisis in patients with sickle cell disease. The ultimate goal of this Phase IIB proposal is to further advance SelG1 into Phase II/III safety and efficacy trials to support of regulatory filings for FDA approval ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Identifying the drug target in dormant cancer cells

    SBC: DORMATARG, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): In spite of billions of dollars spent in the War on Cancer, cancer-specific mortality has changed little as a result, and the vast majority of cures are produced surgically, not from chemotherapy. The main problem is that even with early detection; most cancers still are detected too late and have metastasized before treatment. Although new therapies have less ...

    SBIR Phase I 2012 Department of Health and Human Services
  5. A Small Molecule Targeting Wnt Pathway for Treatment of Diabetic Retinopathy

    SBC: Charlesson, LLC            Topic: NEI

    DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness. This sight-threatening condition has become a public health challenge in the US. Currently, there is no FDA- approved drugfor DR. Laser photocoagulation has remained the gold standard for the treatment of DR over the past two decades. However, laser therapy is usual ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Development of a Miniature Right Heart Support Device

    SBC: Vadovations, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Congestive heart failure (CHF) is one of the most serious medical challenges of our day. With 5 million Americans compromised by the ravages of this disabling disease, CHF is the leading cause of Medicare hospital admissions. The economic burden exceeds 40 billion annually. A comprehensive approach to this ominous healthcare threat includes prevention and earl ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. Antigen Immunoassay for Diagnosis of Coccidioidomycosis

    SBC: Immuno-mycologics, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Coccidioidomycosis, also known as Valley Fever, is a fungal disease caused by Coccidioides spp. that infects an estimated 150,000 people each year in the United States. Current diagnosis of coccidioidomycosis relieson detection of anti-coccidioidal antibodies in patient sera. However, the sensitivity of this serological assay is particularly low in the firs ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. Point-of-care immunoassay for diagnosis of cryptococcosis in HIV/AIDS from whole blood

    SBC: Immuno-mycologics, Inc.            Topic: N/A

    Cryptococcal meningitis (CM) kills more than 600,000 HIV-infected individuals globally per year, with the highest yearly incidence occurring in sub-Saharan Africa. There is a critical need for a simple diagnostic tool for cryptococcosis that can be used in resource-limited countries. An innovative cryptococcal antigen lateral flow assay (CrAg LFA) has been developed in order to address this need. ...

    SBIR Phase I 2012 Department of Health and Human Services

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