Award Data

DESCRIPTION (provided by applicant): Coccidioidomycosis, also known as Valley Fever, is a fungal disease caused by Coccidioides spp. that infects an estimated 150,000 people each year in the United States. Current diagnosis of coccidioidomycosis relieson detection of anti-coccidioidal antibodies in patient sera. However, the sensitivity of this serological assay is particularly low in the firs ...

DESCRIPTION (provided by applicant): In spite of billions of dollars spent in the War on Cancer, cancer-specific mortality has changed little as a result, and the vast majority of cures are produced surgically, not from chemotherapy. The main problem is that even with early detection; most cancers still are detected too late and have metastasized before treatment. Although new therapies have less ...

DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness. This sight-threatening condition has become a public health challenge in the US. Currently, there is no FDA- approved drugfor DR. Laser photocoagulation has remained the gold standard for the treatment of DR over the past two decades. However, laser therapy is usual ...

DESCRIPTION (provided by applicant): Congestive heart failure (CHF) is one of the most serious medical challenges of our day. With 5 million Americans compromised by the ravages of this disabling disease, CHF is the leading cause of Medicare hospital admissions. The economic burden exceeds 40 billion annually. A comprehensive approach to this ominous healthcare threat includes prevention and earl ...

Cryptococcal meningitis (CM) kills more than 600,000 HIV-infected individuals globally per year, with the highest yearly incidence occurring in sub-Saharan Africa. There is a critical need for a simple diagnostic tool for cryptococcosis that can be used in resource-limited countries. An innovative cryptococcal antigen lateral flow assay (CrAg LFA) has been developed in order to address this need. ...