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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Targeting RNA conformation for drug development

    SBC: NUBAD, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for AIDS. Targeting specific RNA- protein interactions, such as Tat-TAR or Rev-RRE, which are involved in proliferation and survival of HIV-1 is a pro ...

    STTR Phase I 2012 Department of Health and Human Services
  2. Online Training Support System for Community-Based Substance Abuse Agencies

    SBC: Sheidow Consulting, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Drug abusing and dependent youth represent a greatly under-served population at high risk of presenting significant deleterious long-term outcomes for themselves, their families, communities and society at extraordinary long-term costs. Adolescent substance use has been linked to serious problems including automobile accidents, increased rates of risky sexual ...

    SBIR Phase I 2012 Department of Health and Human Services
  3. Non-Enzymatic Cryogenic Isolation of Therapeutic Cells

    SBC: Cell & Tissue Systems, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): In modern day medicine, cellular therapies, regenerative medicine and tissue engineering all involve technologies for harvesting, expanding, modifying and re-implanting live viable cells and tissues. Processes for preparing the therapeutic products that incorporate living cells are critical for the stability and potency of th products but may be inherently inju ...

    SBIR Phase I 2012 Department of Health and Human Services
  4. Feasibility of immunotherapy by ice-free cryopreservation of engineered human all

    SBC: Cell & Tissue Systems, Inc.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Autologous regenerative medicine tissue therapy costs are very high because when individual tissues are manufactured all the costs fall on a single patient. Allogeneic tissues are cheaper because large tissue batches can be made and the costs are shared by many patients. Allogeneic tissues are commonly treated to remove cell-associated antigens by decellulariza ...

    SBIR Phase I 2012 Department of Health and Human Services
  5. Development of a novel connexin-based peptide for the treatment of corneal injury

    SBC: FirstString Research, Inc            Topic: NEI

    DESCRIPTION (provided by applicant): According to the World Health Organization, at least 171 million people worldwide are living with diabetes and this figure is likely to more than double by the year 2030. Because of its chronic nature, the severity of its complications and the means required to control them, the economic burden is enormous not only to the individuals and families involved but a ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Neuroprotective agents for retinal diseases

    SBC: Mitochem Therapeutics, LLC            Topic: NEI

    DESCRIPTION (provided by applicant): Retinal degeneration can be triggered by environmental insults as well as genetic mutations. The role for most disease genes is unclear and pathological processes are influenced environment making it difficult to identify one central cause. Indeed, the genetics of age-related macular degeneration (AMD) and other forms of retinal degeneration point to multip ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. A sample stabilization system for HIV in Plasma and Whole Blood

    SBC: ACXEND            Topic: NHLBI

    DESCRIPTION (provided by applicant): Nucleic acid analysis is the essential foundation of many biomedical research and diagnostic methods. Quantitative molecular diagnostic methods are critically dependent on the ability to stabilize the collected sampleprior to purification and analysis. While conventional methods for invasive blood draw procedures exist, there is a desire and movement in both ...

    SBIR Phase I 2012 Department of Health and Human Services

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