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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer

    SBC: JSK THERAPEUTICS INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure. JSK Therapeutics (J ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Implantable Myoelectric Recording Array for Control of Prostheses

    SBC: RIPPLE, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): The goal of this translational SBIR program is to create a small, implantable system for recording myoelectric signals from residual and reinnervated muscles of individuals with forearm and other amputations. The signals will be wirelessly coupled to an external receiver for controlling prostheses. Compared to conventional surface electrodes, this system will p ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. The Memory Care Navigator: A Proactive Guide

    SBC: Proactive Memory Services            Topic: NIA

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is an irreversible neurological disease that progressively causes a tremendous toll in disability and societal cost. As our population ages, AD and other memory disorders will become increasingly prevalent. Patients and their families often find themselves lost in a complex web of multiple providers, receiving conflicting recommend ...

    STTR Phase I 2012 Department of Health and Human Services
  4. In-situ Gelling Protein Polymer Intravascular Embolic Agent for Hepatic Carcinoma

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): This Phase I proposal addresses the significant need for improved treatment options for patients with liver cancer, the fifth highest incidence of cance in the world. Because of the lack of symptoms, hepatocellular carcinoma (HCC) is detected at advanced stages in 84% of cases, for which the 1-year survival rate is 22% and at 5 years it is 5%. The only curativ ...

    STTR Phase I 2012 Department of Health and Human Services
  5. Protease-resistant D-peptide inhibitors of RSV entry

    SBC: NAVIGEN, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is the major cause of severe lower respiratory tract infections in children and infants, affecting an estimated 64 million people and causing 160,000 deaths worldwide per year (WHO). Each year in the United States, ~100,000 infants and ~170,000 adults are hospitalized due to RSV infection. High-risk adults (elderly and patients ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Rapid Comprehensive Identification of Pneumonia Pathogens

    SBC: IDAHO TECHNOLOGY            Topic: NIAID

    DESCRIPTION (provided by applicant): Lower respiratory tract infections (LRTI), including pneumonia, are a significant threat to human health. For example, community-acquired pneumonia and influenza are together the seventh leading cause of death in the United States. There is a wide range of pathogens that can cause pneumonia. Defining the causative organism in pneumonia, however, is complex. St ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. Protease-resistant D-peptide Inhibitors of Ebola Virus Entry

    SBC: NAVIGEN, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Ebola virus (EboV) is a filovirus that causes a highly deadly hemorrhagic fever in humans and non-human primates. Since its discovery in central Africa in 1976, there have been 16 natural human outbreaks with an averagemortality rate of 67%. There are no approved agents to prevent or treat Ebola infection. Due to Ebola's ease of dissemination, high lethali ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. Mesodissection Device

    SBC: AVANSCI BIO, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Mesodissection Device Microscopic analysis of tissue mounted on glass slides is commonly used to study cancer, nonneoplastic entities such as heart disease and diabetes, and normal cell function. At a growing rate, researchers are utilizing various micro and macro tissue dissection techniques to recover specific areas of interest from a slide mounted tissue sec ...

    SBIR Phase I 2012 Department of Health and Human Services
  9. Automated Macrodissection Device

    SBC: AVANSCI BIO, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Microscopic examination of formalin fixed, paraffin embedded (FFPE) tissue sections mounted on glass slides is the cornerstone of clinical histopathology. Ancillary molecular testing is often required for diagnosis, risk stratification, ad treatment planning, particularly in cancer. Molecular testing often involves mutation or expression analysis of nucleic aci ...

    SBIR Phase I 2012 Department of Health and Human Services
  10. Submerged Printing of Lipid and Membrane Protein Arrays

    SBC: Carterra, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The goal of this Phase I SBIR project is to develop a device for automated array printing of lipids and membrane proteins onto submerged microtiter plate surfaces in a way that maintains their activity and function. Ourproprietary 3D microfluidic printing technology is uniquely capable of sealing and printing arrays of biomolecules onto submerged surfaces in a ...

    SBIR Phase I 2012 Department of Health and Human Services

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