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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Point of Care Detection of Respiratory Viruses

    SBC: LUCIGEN CORPORATION            Topic: NIAID

    DESCRIPTION (provided by applicant): Respiratory infections have a significant health and economic impact worldwide. Current test products for the diagnosis of respiratory viral infections such as influenza are inadequate for the timely diagnosis needed for successful implementation of antiviral treatment. Unfortunately a test product that can accurately diagnose common respiratory viruses with hi ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Random Shear Shuttle BAC Libraries for Antimicrobial Discovery from Soil Metageno

    SBC: LUCIGEN CORPORATION            Topic: NIAID

    DESCRIPTION (provided by applicant): 100,000 Americans perish each year due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant. The best possible source for new antibiotic structures with potentially novel mechanisms of action is within natural environments, particularly s ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Engineered tissue-based, high-throughput compound profiling

    SBC: INVIVOSCIENCES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Current NIGMS-SBIR funding supported InvivoSciences LLC's (IVS) launch of several product lines in 2010. IVS generated revenues from the sales of three-dimensional (3D) cell culture tools (MC-8TM and IVS InsertsTM) thatcan grow various hydrogel tissues without any support layers. The culture tools enable Palpator TM and Tissue StretcherTM to stretch the hy ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. NOVEL SOLUBILITY-ENHANCING PROTEIN EXPRESSION TECHNOLOGY

    SBC: LUCIGEN CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): A major goal in the post-genomic era is to express the vast collection of protein- coding sequences, eventually resulting in a better understanding of protein interactions and the development of novel therapeutics. Themost favored host for heterologous recombinant protein expression is Escherichia coli. Despite many improvements, producing soluble proteins in E ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Intelligent Prosthetic Socket with Variable Volume and Elevated Vacuum Systems

    SBC: SMART SURFACE DESIGNS, LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): Patient socket performance is a critical barrier to progress in rehabilitation, the most common source of patient dissatisfaction and part of a growing medical and socioeconomic problem. Poor socket performance is a greatly uncharacterized multi-factorial problem that leads to skin degeneration and patient discomfort (~75% of all patients). This proposal has a ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Screening Device for Differentiated Primary Cell Models of Airway Epithelia

    SBC: Bellbrook Labs, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Approaches to drug screening typically involve dramatic compromises in order to achieve high throughput and hold down costs. Examples include the use of immortalized, heterologous cell lines, and genetic engineering toover-express the target protein and/or incorporate a fluorescent surrogate reporter to display the result. At least partly because such systems o ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Targeting System Xc- for the Treatment of Schizophrenia

    SBC: Promentis Pharmaceuticals            Topic: NIMH

    DESCRIPTION (provided by applicant): Schizophrenia is a chronic and debilitating disorder that impacts nearly 1% of the world's population. The burden on the families and caregivers of patients is immense, with the cost of care in the United States being greater than 60 billion annually. The exorbitant financial strain of schizophrenia arises, in large part, to a lack of innovation that has ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Automated Interactive Text Messaging to Assess Adolescent Depression

    SBC: KOBAK, KENNETH A            Topic: NIMH

    DESCRIPTION (provided by applicant): The internet is an increasingly important resource for clinicians to access training materials and resources for treatment delivery of evidence-based treatments such as cognitive behavioral therapy (CBT) and antidepressant medications. This project proposes to develop a secure, web-based resource to provide therapists with instructional materials for scheduling ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Modeling Professional Attitudes and Teaching Humanistic Communication in VR

    SBC: MEDICAL CYBERWORLDS, INC.            Topic: NCATS

    DESCRIPTION (provided by applicant): Modeling Professional Attitudes and Teaching Humanistic Communication in VR (MPathic-VR) Patients with life-threatening cancer need caregivers who can help them through difficult decisions by understanding their interests, values, and beliefs, and who communicate empathically with the patient's family and friends, and effectively with their medical peer ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. Speech-based biomarkers of CNS dysfunction associated with early Alzheimers disea

    SBC: KOBAK, KENNETH A            Topic: NIA

    DESCRIPTION (provided by applicant): More efficient methods to screen and monitor elderly patients in clinical practice and research are needed, but visits to clinical offices are expensive and many older patient are restricted by mobility or transportation access. The Alzheimer's Disease Cooperative Study (ADCS) is evaluating several technology platforms for remotely monitoring patient stat ...

    STTR Phase I 2012 Department of Health and Human Services

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