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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Pediatric Acceptable Formulation of Amiodarone

    SBC: ACADEMIC PHARMACEUTICALS INC            Topic: N/A

    DESCRIPTION (provided by applicant): IV amiodarone is the first line therapy for life threatening ventricular as well as supraventricular arrhythmias. However, the Tween 80 and benzyl alcohol diluents limits the rate of administration severely, due to hypotension and myocardial contractile depression. These adverse toxicities contribute to the high mortality of cardiac arrest patients who have ma ...

    SBIR Phase I 2009 Department of Health and Human Services
  2. Controlled Release Vascular Grafts

    SBC: VesselTek Biomedical LLC            Topic: N/A

    DESCRIPTION (provided by applicant): In the United States, it is estimated that 8 million people suffer from peripheral artery disease (PAD). PAD is characterized by a gradual reduction in blood flow to the muscular arteries of the lower extremities caused by atherosclerosis. For those with severe PAD, lower extremity bypass grafting remains the predominant option for limb salvage. Although native ...

    SBIR Phase I 2009 Department of Health and Human Services
  3. Non-invasive Assessment of Insulin Resistance

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this grant is to develop a non-invasive method for assessment of insulin resistance and impaired glucose tolerance (IGT) as a measure of pre-diabetes suitable for application to large-scale screening studies and to individualized preventive strategies in patients at risk for development of diabetes. This new approach is based on the kno ...

    SBIR Phase II 2009 Department of Health and Human Services
  4. Development of novel tissue directed ultra sound therapeutic gene delivery system

    SBC: SONOGENE, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Low levels of high-density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease (CHD). HDL cholesterol levels are predictive of major cardiovascular events in patients treated with statins. This relationship was also observed among patients with LDL cholesterol levels below 70 mg per deciliter. Studies have demonstrated that poly ...

    SBIR Phase I 2009 Department of Health and Human Services
  5. Instrument for assessment of pediatric binaural hearing abilities

    SBC: COMPREVAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The practice of evidence-based audiological (re)habilitation requires efficient, easy to use, standardized outcome assessment protocols and instruments with known reliability and validity. Such protocols and instruments are especially important for assessing the speech communication benefits of cochlear implants (CIs) in adults and children. The standard of car ...

    SBIR Phase I 2009 Department of Health and Human Services
  6. Wide Angle X-ray Scattering for Commercial Applications in Drug Lead Discovery

    SBC: SHAMROCK STRUCTURES LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this project is to develop the use of wide-angle x-ray solution scattering (WAXS) as a routine screening tool for detection of functional interactions between proteins of therapeutic interest and small molecule ligands for the purposes of drug discovery and development. The process of lead discovery presents an early and significant bottleneck in th ...

    SBIR Phase I 2009 Department of Health and Human Services
  7. Development Of A Next-Generation Thrombelastograph

    SBC: CORAMED TECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by applicant): Coramed is designing a next-generation point-of-care (POC) instrument, the TEG 6500, for monitoring patient hemostasis on demand. The instrument will introduce a completely new technology for monitoring clot formation and breakdown that is well suited for the continuum of settings from inside the hospital, to ambulatory care clinics, physician offices, and pati ...

    SBIR Phase II 2009 Department of Health and Human Services
  8. FirstAuthor- A Writing Process Software Tool

    SBC: DON JOHNSTON, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The education reform initiative, No Child Left Behind Act of 2001 (NCLBA) signed into law by President Bush in January of 2002, emphasized the critical role of literacy in the lives of all children. Writing is an important, but often neglected, part of literacy instruction. Software tools that support the needs of a beginning writer, especially those with speci ...

    STTR Phase I 2009 Department of Health and Human Services
  9. Engineering industrial fermentations for renewable amino acid coproducts

    SBC: FERMALOGIC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Knowledge of amino acid metabolism is critical to human health and has significant industrial applications as well. This study proposes to develop a coproduct method for the production of L-lysine, an essential amino acid of great economic and industrial importance. If successful, the L-lysine produced as a result of this study will be a coproduct of the erythr ...

    SBIR Phase I 2009 Department of Health and Human Services
  10. Software to Facilitate DNA Cloning

    SBC: GSL BIOTECH, LLC.            Topic: N/A

    DESCRIPTION (provided by applicant): DNA cloning, also known as gene splicing or recombinant DNA technology, underlies all of modern biomedical and biotechnology research. Yet DNA cloning frequently goes awry because this process involves a large number of variables, has many subtleties, and is hard to document with existing tools. DNA cloning is linked to a variety of other procedures, and resear ...

    SBIR Phase II 2009 Department of Health and Human Services

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