Award Data

DESCRIPTION (provided by applicant): IV amiodarone is the first line therapy for life threatening ventricular as well as supraventricular arrhythmias. However, the Tween 80 and benzyl alcohol diluents limits the rate of administration severely, due to hypotension and myocardial contractile depression. These adverse toxicities contribute to the high mortality of cardiac arrest patients who have ma ...

DESCRIPTION (provided by applicant): In the United States, it is estimated that 8 million people suffer from peripheral artery disease (PAD). PAD is characterized by a gradual reduction in blood flow to the muscular arteries of the lower extremities caused by atherosclerosis. For those with severe PAD, lower extremity bypass grafting remains the predominant option for limb salvage. Although native ...

DESCRIPTION (provided by applicant): The overall objective of this grant is to develop a non-invasive method for assessment of insulin resistance and impaired glucose tolerance (IGT) as a measure of pre-diabetes suitable for application to large-scale screening studies and to individualized preventive strategies in patients at risk for development of diabetes. This new approach is based on the kno ...

DESCRIPTION (provided by applicant): Low levels of high-density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease (CHD). HDL cholesterol levels are predictive of major cardiovascular events in patients treated with statins. This relationship was also observed among patients with LDL cholesterol levels below 70 mg per deciliter. Studies have demonstrated that poly ...

DESCRIPTION (provided by applicant): The practice of evidence-based audiological (re)habilitation requires efficient, easy to use, standardized outcome assessment protocols and instruments with known reliability and validity. Such protocols and instruments are especially important for assessing the speech communication benefits of cochlear implants (CIs) in adults and children. The standard of car ...

DESCRIPTION (provided by applicant): The goal of this project is to develop the use of wide-angle x-ray solution scattering (WAXS) as a routine screening tool for detection of functional interactions between proteins of therapeutic interest and small molecule ligands for the purposes of drug discovery and development. The process of lead discovery presents an early and significant bottleneck in th ...

DESCRIPTION (provided by applicant): Coramed is designing a next-generation point-of-care (POC) instrument, the TEG 6500, for monitoring patient hemostasis on demand. The instrument will introduce a completely new technology for monitoring clot formation and breakdown that is well suited for the continuum of settings from inside the hospital, to ambulatory care clinics, physician offices, and pati ...

DESCRIPTION (provided by applicant): The education reform initiative, No Child Left Behind Act of 2001 (NCLBA) signed into law by President Bush in January of 2002, emphasized the critical role of literacy in the lives of all children. Writing is an important, but often neglected, part of literacy instruction. Software tools that support the needs of a beginning writer, especially those with speci ...

DESCRIPTION (provided by applicant): Knowledge of amino acid metabolism is critical to human health and has significant industrial applications as well. This study proposes to develop a coproduct method for the production of L-lysine, an essential amino acid of great economic and industrial importance. If successful, the L-lysine produced as a result of this study will be a coproduct of the erythr ...

DESCRIPTION (provided by applicant): DNA cloning, also known as gene splicing or recombinant DNA technology, underlies all of modern biomedical and biotechnology research. Yet DNA cloning frequently goes awry because this process involves a large number of variables, has many subtleties, and is hard to document with existing tools. DNA cloning is linked to a variety of other procedures, and resear ...