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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Pediatric Acceptable Formulation of Amiodarone

    SBC: ACADEMIC PHARMACEUTICALS            Topic: N/A

    DESCRIPTION (provided by applicant): IV amiodarone is the first line therapy for life threatening ventricular as well as supraventricular arrhythmias. However, the Tween 80 and benzyl alcohol diluents limits the rate of administration severely, due to hypotension and myocardial contractile depression. These adverse toxicities contribute to the high mortality of cardiac arrest patients who have ma ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  2. Novel approaches to extending glucose sensor lifespan

    SBC: AEGIS BIOSCIENCES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Long term transcutaneous devices such as catheters; require patients to endure extended skin breaches (wounds) that can be difficult to manage clinically, i.e. infection and inflammation. These complications not only shorten device lifespan, but also compromise patient health. In the case of short-term commercial transcutaneous glucose sensors, FDA has approved ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  3. Controlled Release Vascular Grafts

    SBC: VesselTek Biomedical LLC            Topic: N/A

    DESCRIPTION (provided by applicant): In the United States, it is estimated that 8 million people suffer from peripheral artery disease (PAD). PAD is characterized by a gradual reduction in blood flow to the muscular arteries of the lower extremities caused by atherosclerosis. For those with severe PAD, lower extremity bypass grafting remains the predominant option for limb salvage. Although native ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Small-molecule TNF-a Modulators as Chemoprotective Agents

    SBC: 21ST CENTURY THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Cisplatin is a widely used cytotoxic agent with therapeutic activity against various tumors, but also with substantial side effects, including nephrotoxicity, hepatotoxicity and myelosuppression. Therefore, a chemoprotective agent which reduces the side effects of cisplatin without affecting it efficacy would have significant clinical benefit. Currently, amifos ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  5. Pandemic H5N1 vaccine containing recombinant H5 and a synthetic TLR4 agonist, GLA

    SBC: TRIA BIOSCIENCE CORP.            Topic: N/A

    DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global pandemic catastrophe. Vaccines are the cornerstone strategy for combating avian flu but there are numerou ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  6. RATIONAL DESIGN OF SURAMIN ANALOG CANCER AND AIDS DRUGS

    SBC: Ardono Research            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  7. Designed Bioactive Scaffolds for Mandibular Reconstruction

    SBC: TISSUE REGENERATION SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Craniomaxillafacial (CMF) reconstruction remains a significant challenge due to the complex geometry and the need to restore both esthetics and function, especially for large mandibular segmental defects resulting from tumor resection, trauma or congenital defects. The current clinical gold standard, vascularized free bone flap (VBF), still suffers significant ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  8. SIMPLE RELIABLE LOW-COST VASOVASOSTOMY SYSTEM

    SBC: AVATAR DESIGN AND DEVELOPMENT, INC.            Topic: N/A

    THE LONG-TERM OBJECTIVE IS TO MAKE AVAILABLE TO UROLOGISTS AND SPECIALLY TRAINED TEAMS OF TECHNICIANS THROUGHOUT THE WORLD A SIMPLE, RELIABLE, LOW-COST MACROSURGICAL VASOVASOSTOMY SYSTEM. OFFERED IN A RESTOCKABLE KIT FORMAT, THE ARMAMENTARIUM WOULD INCLUDE A VAS LUMEN SIZING GAUGE, A SELECTION OF FLOW-THROUGH ABSORBABLE VAS STENTS, MICROSUTUTERS, AN IMPROVED VAS STABILIZING CLAMP, AND TWO SPECIAL ...

    SBIR Phase II 1990 Department of Health and Human Services
  9. DIGITAL IMAGING FOR SKIN GRAFT VIABILITY

    SBC: BARLOW SCIENTIFIC, INC.            Topic: N/A

    THE LONG TERM GOAL OF THIS RESEARCH IS TO DEVELOP AN IMAGING SYSTEM TO EVALUATE VIABILITY OF VASCULARIZED SKIN GRAFTS. TOWARDS THIS END IT IS PROPOSED TO CONSTRUCT AND EVALUATE A DIGITIZED IMAGER THAT WILL VISUALLY DISPLAY TWO PARAMETERS THAT CORRELATE WITH SKIN GRAFT VIABILITY. THE FIRST TECHNIQUE WILL MEASURE DIFFERENTIAL BLOOD VOLUME BETWEEN SYSTOLE AND DIASTOLE PHASES OF ARTERIAL CIRCULATION B ...

    SBIR Phase II 1990 Department of Health and Human Services
  10. TISSUE TEMPERATURE BY NEAR-INFRARED SPECTROSCOPY

    SBC: BARLOW SCIENTIFIC, INC.            Topic: N/A

    THE LONG-TERM GOAL OF THIS RESEARCH IS TO DEVELOP OPTICAL INSTRUMENTS AND METHODS FOR MEASURING AND IMAGING TISSUE TEMPERATURE. IN PHASE I, TECHNIQUES WILL BE DEVELOPED THAT COMPUTE TEMPERATURE READINGS FROM NEAR-INFRARED (NIR) ABSORPTION BANDS OF WATER. THE EFFECT OF INTERFERENCE ON SUCH MEASUREMENTS FROM OTHER TISSUE COMPONENTS WILL BE DETERMINED. IN THE INITIAL STUDIES TO BE PERFORMED DURING PH ...

    SBIR Phase I 1990 Department of Health and Human Services
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